Principal Director, Surgical Oncology, BLK-Max Super Speciality Hospital, New Delhi
Part 2 of 9 in Breast Cancer - Diagnosis and Surgical Management
Diagnosing a Breast Lump: Imaging Sequence, BI-RADS and When to Biopsy
September 21, 2025
When a patient presents with a breast lump, imaging always comes before biopsy, since a needle biopsy creates a micro-haematoma that distorts the anatomy and degrades subsequent imaging. Both breasts must always be imaged together, even when only one side is symptomatic, since unilateral imaging is never sufficient.
Choosing the right imaging by age
Patients under 40 should have bilateral ultrasound, since younger breast tissue is predominantly glandular rather than fatty, which mammography cannot read reliably. Patients 40 and older should have bilateral mammography instead, since fat becomes the dominant tissue with age and mammography reads fatty tissue far better. MRI is reserved for specific situations: when mammogram or ultrasound findings are inconclusive, when multicentric disease across several quadrants needs to be mapped before considering breast conservation, or when a patient presents with an axillary node but no visible primary lesion on standard imaging.
Reading the report: the BI-RADS system
BI-RADS (Breast Imaging Reporting and Data System) categorises findings from 0 to 6: BI-RADS 0 means the workup is incomplete and needs further imaging; BI-RADS 1 is a normal breast; BI-RADS 2 is a benign finding requiring only yearly follow-up imaging; BI-RADS 3 is probably benign, biopsied only in selected high-risk cases, such as strong family history or known BRCA positivity; BI-RADS 4 and 5 must always be biopsied; and BI-RADS 6 confirms a malignancy already proven by prior biopsy. A true-cut or core needle biopsy, not fine needle aspiration, is required to properly establish cancer type and hormone receptor status; FNAC is reserved specifically for confirming whether an axillary node is involved when the primary breast lesion itself already has a clear diagnosis.
This article is based on a Jivo Masterclass session conducted by Dr. Rajesh Kumar Jain, Principal Director, Surgical Oncology, BLK-Max Super Speciality Hospital, New Delhi. The article has been summarised with the assistance of an AI tool from the original masterclass recording. Watch the full Masterclass recording
Looking for a breast cancer or surgical oncology consultation or a second opinion? Get in touch with the Jivo team
This guide is based on a live Jivo Masterclass — Dr. Rajesh Kumar Jain taught doctors across Africa on September 21, 2025.
FROM THE LIVE Q&A
Dr. Abraham
If it is familial, should bilateral surgery be done without any further testing?
Dr. Rajesh Kumar Jain
No, a BRCA1 and BRCA2 test should be done first. Indications for testing are all triple-negative breast cancer, a strong first-degree family history (a sister, mother, or maternal or paternal aunt with breast cancer), and any history of male breast cancer in the family, which alone is enough to warrant testing. If the BRCA test comes back positive, mastectomy of the affected breast should be combined with prophylactic mastectomy of the opposite side. If BRCA testing isn't available locally, it can be arranged through Dr. Jain's centre.
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Frequently Asked Questions
What is the definitive treatment for breast cancer?▼
There is no single definitive treatment; breast cancer, like all solid tumours, requires multimodal treatment. Chemotherapy alone, radiotherapy alone, or hormone therapy alone cannot cure it. Surgery has to be part of the treatment plan for a cure, combined with hormone therapy, chemotherapy or radiation as indicated, though surgery alone is occasionally sufficient in very select cases.
Is rehabilitative management necessary after breast cancer treatment?▼
It's mandatory, and Dr. Jain considers it roughly 95% of overall cancer management. Physical rehabilitation covers arm exercises and lifelong protection of the affected arm, no rings, blood pressure cuffs or needles on that side. Psychological rehabilitation matters just as much, since patients carry real emotional weight after a cancer diagnosis, and in some settings social rehabilitation is needed too, since patients can lose their jobs, or in some communities face marital breakdown, because of the diagnosis.
What is the prognosis for breast cancer treatment?▼
Prognosis is improving steadily. Five-year survival is around 97-98% for stage one, 90-95% for stage two, 80-85% for stage three, and even stage four disease has a 25-30% five-year survival rate. Triple-negative and locally advanced cases carry a higher recurrence risk specifically, so they need especially stringent follow-up to catch any recurrence early enough to treat.
What is the cost implication of breast cancer treatment?▼
Surgery alone, all-inclusive, costs roughly $5,000. Chemotherapy adds around $10,000, and radiation is roughly $3,500 to $4,000. Extended targeted therapy such as trastuzumab can add another $10,000, though that portion can often be continued at the patient's home location. As a rough guide, surgery plus basic chemotherapy runs around $15,000 for most patients, and cases involving genuine financial hardship can always be discussed.
Other than PET CT, how can breast cancer be staged using ultrasound and CT scan in a limited setup?▼
A whole-abdomen ultrasound, not just the upper abdomen, checks for liver metastasis and also covers the ovaries and uterus. A chest X-ray checks for lung metastasis. For bone, a skeletal survey, plain X-rays covering the spine, skull and limbs, substitutes for a bone scan where nuclear medicine isn't available. This combination is less accurate than PET CT but is a reasonable, optimal fallback when resources are limited.
Should a breast lump be imaged or biopsied first?▼
Imaging always comes first. A needle biopsy creates a micro-haematoma that distorts the anatomy and makes subsequent imaging less reliable.
What imaging should be used for a breast lump, by age?▼
Bilateral ultrasound for patients under 40, since younger breast tissue is predominantly glandular; bilateral mammography for patients 40 and older, since mammography reads the more fatty tissue typical of that age group far better. MRI is reserved for inconclusive findings, mapping multicentric disease, or an axillary node with no visible primary.
In This Series: Breast Cancer - Diagnosis and Surgical Management
- 1.Breast Cancer Diagnosis and Surgical Management
- 2.Diagnosing a Breast Lump: Imaging Sequence, BI-RADS and When to Biopsy
- 3.Staging Breast Cancer, Including in Settings Without PET CT
- 4.Breast Conservation Surgery vs Mastectomy: How the Decision Is Made
- 5.Axillary Management in Breast Cancer: Sentinel Biopsy and the LYMPHA Technique
- 6.When Chemotherapy Can Be Avoided: Genomic Risk-Stratification in Early Breast Cancer
- 7.BRCA Testing in Breast Cancer: Who Needs It and What Positive Results Mean
- 8.Breast Reconstruction After Mastectomy: Options and Timing
- 9.Rehabilitation and Prognosis After Breast Cancer Treatment