Additional Director, Urology, Fortis Hospital, Shalimar Bagh, New Delhi
Part 2 of 8 in Prostate Cancer: Diagnosis and Latest Treatment Guidelines
Prostate Cancer Risk Factors and How It Presents
May 5, 2024
Prostate cancer is the second most commonly diagnosed cancer in men, with about 1.4 million diagnoses and 375,000 deaths worldwide each year; its incidence in Africa is believed to be particularly high, at around 29 new cases and 16 deaths per 100,000 people.
Who is at risk
Increasing age is the single biggest risk factor: in the 80-90 age group, 80% of men have some focus of prostate cancer on autopsy, rising to 90% above age 90. A strong family history is also a major risk factor, and the disease is more common in men of African descent and African-American men, with some dietary factors also contributing.
How it presents
Early, organ-confined prostate cancer is usually asymptomatic and is picked up incidentally through PSA blood screening. Locally advanced disease can cause obstructive urinary symptoms: hesitancy, an intermittent or weak stream, or straining to urinate, sometimes with blood in the urine or semen. When the cancer has spread to lymph nodes, it can cause leg swelling and perineal discomfort; when it has spread to bone, it can cause bone pain, fractures or even lower-limb paralysis.
This article is based on a Jivo Masterclass session conducted by Dr. Anurag Puri, Additional Director, Urology, Fortis Hospital, Shalimar Bagh, New Delhi. The article has been summarised with the assistance of an AI tool from the original masterclass recording. Watch the full Masterclass recording
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This guide is based on a live Jivo Masterclass: Dr. Anurag Puri taught doctors across Africa on May 5, 2024.
FROM THE LIVE Q&A
Moderator
Which PSA test is more specific for diagnosis: total PSA or free PSA?
Dr. Anurag Puri
Total PSA is checked first and should not by itself guide a biopsy decision; if there is doubt, it should be repeated after two to three weeks. When total PSA is borderline (4 to 10) and there is still doubt, a free PSA test helps: a free PSA under 10% of total PSA leans towards malignancy, while over 25% suggests a lower chance of malignancy.
Frequently Asked Questions
Who should perform an ultrasound-guided prostate biopsy: a urologist or an interventional radiologist?▼
Both can perform it, but a urologist is better equipped to manage complications if they occur, such as bleeding in the urine or from the rectum.
Is there a specific disease stage for which robotic treatment is used?▼
Robotic radical prostatectomy is used for low-risk and intermediate-risk disease, and can be used for high-risk disease too, provided the lymph nodes are not involved, in which case it is combined with an extended lymph node dissection. If the lymph nodes are already positive, radical surgery is not performed.
Should a PSA test be sent for all patients with BPH?▼
It is not mandatory as routine screening, but a baseline PSA is checked before starting an anti-androgen such as dutasteride, which is commonly prescribed for BPH.
What is the benefit of alfuzosin in the symptomatic management of BPH, and is there a newer drug?▼
Alfuzosin is a commonly used drug that relieves the urinary symptoms of BPH. Silodosin is a newer, more potent alternative. Alfuzosin is generally preferred in younger, sexually active men, while silodosin is preferred in older patients because of its sexual side-effect profile.
Is there really no treatment available for prostate cancer above the age of 80?▼
That is not the case. Between the ages of 80 and 90, up to 80% of men are found to harbour some focus of prostate cancer, but most die of other causes rather than the cancer itself. Because it is often a low-risk, indolent disease in this age group, treatment is sometimes deliberately avoided if the patient is asymptomatic.
What are the main risk factors for prostate cancer?▼
Increasing age is the biggest factor, along with a strong family history; the disease is also more common in men of African descent.
What are the symptoms of prostate cancer?▼
Early disease is usually asymptomatic and found via PSA screening; locally advanced disease can cause obstructive urinary symptoms, and spread to lymph nodes or bone can cause leg swelling, bone pain or fractures.
In This Series: Prostate Cancer: Diagnosis and Latest Treatment Guidelines
- 1.Prostate Cancer
- 2.Prostate Cancer Risk Factors and How It Presents
- 3.Diagnosing Prostate Cancer: PSA, Biopsy and Staging
- 4.Gleason Score and Risk Stratification in Prostate Cancer
- 5.Prostate Cancer Treatment: From Active Surveillance to Robotic Surgery
- 6.Advanced and Hormone-Resistant Prostate Cancer Management
- 7.Managing BPH: Medications and When Size Doesn't Matter
- 8.When to Refer a Prostate Cancer Patient for Treatment Abroad