UrologyDr. Anurag PuriProstate Cancer

Additional Director, Urology, Fortis Hospital, Shalimar Bagh, New Delhi

Part 8 of 8 in Prostate Cancer: Diagnosis and Latest Treatment Guidelines

When to Refer a Prostate Cancer Patient for Treatment Abroad

May 5, 2024

For doctors treating patients outside India, knowing when and how to refer a prostate cancer patient matters as much as the clinical management itself.

When to refer

Every stage of prostate cancer requires some form of treatment, so it is more useful to ask which patients should not be referred rather than which should. Referral becomes appropriate when a local setup cannot offer the full appropriate treatment for a given stage, such as PET scans, radiotherapy or robotic surgery, or when a patient is too frail to safely travel. Earlier referral, ideally while the patient is still asymptomatic, gives better outcomes.

PSMA PET scans and confirming metastasis

For a locally advanced (T4) tumour with no metastasis found on local imaging, a PSMA PET scan, the most specific imaging test for prostate cancer spread, should be repeated once the patient reaches India, since this test is often unavailable locally. Confirming the absence of metastasis matters directly for prognosis: prostate cancer is one of the slower-growing cancers, and life expectancy can remain good if metastasis is genuinely absent.

This article is based on a Jivo Masterclass session conducted by Dr. Anurag Puri, Additional Director, Urology, Fortis Hospital, Shalimar Bagh, New Delhi. The article has been summarised with the assistance of an AI tool from the original masterclass recording. Watch the full Masterclass recording

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This guide is based on a live Jivo Masterclass: Dr. Anurag Puri taught doctors across Africa on May 5, 2024.

FROM THE LIVE Q&A

MO

Moderator

Does declining male sexual performance with age relate to atherosclerotic changes in penile vessels? Is there a better urological explanation?

AP

Dr. Anurag Puri

Yes - this is generally due to atherosclerosis: as blood vessels narrow with age, blood supply to the penis decreases, and this reduced blood flow is the main driver of declining sexual performance.

See all 23 questions from this masterclass →

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Frequently Asked Questions

What are the principles of prostate cancer management, the survival rates by stage, and can advanced disease be managed locally?

Management is decided by the disease's staging and parameters: PSA level, Gleason score, and clinical stage on digital rectal examination. Survival rates vary sharply by stage - low-risk, early disease has close to a 100% cure rate, and even metastatic (stage four) patients now have meaningfully better life expectancy with appropriate treatment than with many other stage-four cancers.

What does a kidney transplant require if the donor's genetic makeup is different, and what can be done to restore a failing transplanted kidney?

Kidney transplant is the treatment of choice for renal failure, and results are best with a related, genetically matched donor. Even without a genetic match or matching blood group, plasmapheresis, an advanced technique that lowers the antigenicity of the donor organ, can still allow a transplant to proceed.

Is it true that many patients who undergo prostate surgery end up dying, as some patients believe?

This is a misconception. The great majority of prostate operations are for benign BPH and are done endoscopically with little morbidity; patients are very satisfied. Even for cancer, with modern robotic surgery, hospital stay is just about three days, and patients are often fit to fly home within two to three weeks without a catheter.

Can a combination of tamsulosin and finasteride eradicate BPH?

No - this combination provides symptomatic relief rather than eradication. Tamsulosin relaxes the prostate to improve urinary flow, while finasteride can shrink the size of the prostate over time, but neither eliminates the underlying benign enlargement.

How do you decide between chemotherapy, radiotherapy, hormone therapy and prostatectomy for a patient?

It depends entirely on the stage. Early, organ-confined disease is treated with curative intent using robotic radical prostatectomy or radiotherapy. Locally advanced disease (spread just outside the prostate but not to lymph nodes or bone) may still use surgery or radiotherapy, combined with androgen deprivation therapy. Disease that has spread more widely and is not surgically resectable is treated less aggressively, with radiotherapy plus hormone deprivation. Metastatic disease (spread to bone) is treated with intent to suppress rather than cure, using hormonal suppression (surgical orchidectomy or depot injections). Hormone-resistant disease, where the cancer no longer responds to hormone deprivation, needs chemotherapy (docetaxel) or oral agents such as abiraterone or enzalutamide.

When should a prostate cancer patient be referred abroad for treatment?

When the local setup cannot offer the appropriate treatment for that disease stage (PET scans, radiotherapy, robotic surgery) or the patient is too frail to travel; earlier referral gives better outcomes.

Why is a PSMA PET scan repeated once a patient arrives in India?

It's the most specific imaging test for prostate cancer spread and is often unavailable locally, so confirming metastasis status directly affects prognosis and treatment planning.

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