Senior Director, Surgical Oncology, Fortis Hospital, Vasant Kunj, New Delhi
Part 4 of 10 in When to Suspect Cancer and How to Refer
Persistent Hoarseness and Laryngeal Cancer: Warning Signs and Voice Rehabilitation
January 25, 2026
Persistent, unexplained hoarseness is a symptom Dr. Shubham Jain says clinicians should take seriously, particularly in patients with specific risk factors.
When hoarseness needs urgent evaluation
He flags concern when the patient has a tobacco history, is over 45 years of age, has recent loosening of teeth, an unexplained neck lump, unexplained oral ulceration, a lump in the lip or oral cavity, or red or white patches in the mouth. He also notes that hoarseness can arise not just from cancers of the throat but from lung or oesophageal cancers affecting the recurrent laryngeal nerve as it courses through the chest, which is why he stresses that a surgical oncologist’s opinion is important since symptoms can mask more than one disease.
Rehabilitating the voice after laryngectomy
Dr. Jain shared the case of a patient from Ethiopia who had already received radiation for laryngeal cancer but had residual disease, requiring surgical removal of the voice box. A voice prosthesis was fitted, allowing him to speak after surgery. A second rehabilitation option is the electrolarynx, an external prosthesis that attaches to the skin and produces vibrations at high speed, which the patient uses to vocalise, giving a more mechanical-sounding voice than a prosthesis but avoiding a further invasive procedure.
Screening for oral cancers
For patients at high risk of cancers of the mouth, Dr. Jain recommends routine self-examination of the mouth every one to two months to catch a new ulcer or patch early enough to bring to medical attention.
This article is based on a Jivo Masterclass session conducted by Dr. Shubham Jain, Senior Director, Surgical Oncology, Fortis Hospital, Vasant Kunj, New Delhi. The article has been summarised with the assistance of an AI tool from the original masterclass recording. Watch the full Masterclass recording
Looking for a diagnosis or treatment for a laryngeal or oral cancer? Get in touch with the Jivo team
This guide is based on a live Jivo Masterclass — Dr. Shubham Jain taught doctors across Africa on January 25, 2026.
FROM THE LIVE Q&A
Dr. Oronana Paul Edugbo
What are the latest screening tests available for early detection of different cancers?
Dr. Shubham Jain
Tumour markers can be used, but it is important to understand the patient's age, family history and smoking status first. At a basic level, a mammography for women, an ultrasound of the whole abdomen for endometrial or ovarian cancer, a serum PSA blood test for men with suspected prostate cancer, and a CT scan of the chest for smokers can be recommended. The frequency varies: colon cancer screening can be a colonoscopy every ten years, or a sigmoidoscopy with a faecal occult blood test.
Frequently Asked Questions
Biopsy is often the best way to detect cancer, but it usually takes a long time. Are there any faster options or alternatives?▼
This is a real issue even in India, where processing time for biopsies can be high in some regions. One workaround is relying more on FNAC, which is not the best strategy but can guide treatment decisions in select situations where a diagnosis is otherwise delayed. A second option is a frozen section facility, which gives some confirmation quickly but is resource-intensive and usually only available at high-volume cancer centres. Short of that, it is best to refer to an oncologist who can guide where a biopsy should be taken from for the best results.
What are the myths in assessing suspected cancer patients?▼
The most important myth is patients' hesitancy to get a biopsy done, fearing it will cause the cancer to spread. A biopsy is one of the most crucial tests a cancer patient needs, and if planned and performed correctly it will not cause the cancer to spread. Another myth is that patients believe cancer is their own fault, from dietary habits or indulgences like tobacco or alcohol. More cases are now understood to happen because of environment or genetics rather than a patient's own fault, and it is important to destigmatise patients suffering from cancer, since stigma is what keeps them from seeking timely treatment.
Do you recommend breast conservation surgery for a small breast ductal carcinoma of the left breast?▼
Definitely. Breast conservation surgery is one of the advanced techniques for treating early breast cancer and is routinely discussed as a possibility with patients. It offers a definite cosmetic advantage, but it needs to be followed up with radiotherapy, and there are strict criteria on imaging and family history that must be met before it is offered. It is now combined with oncoplasty, which improves how the scars are closed for a better cosmetic outcome.
How do we approach cancer of unknown primary with only liver metastases or oligometastases?▼
This is a tricky situation where metastatic deposits are seen without knowing where they are coming from. A PET scan is needed to confirm there is no other site of disease in the body, and immunohistochemistry on the biopsy can give clues to where the cancer is arising from, guiding directed and targeted imaging afterward. Many times the primary is never found. If there are only liver metastases, treatment starts with a palliative intent, and depending on how the patient responds and their performance status, a curative approach involving surgery may later be attempted, though nothing can be assured to the patient in advance.
What is your take on mebendazole and ivermectin as adjunct tablets for cancer treatment?▼
These are being evaluated as adjuvant therapy for cancer, but there is not yet sufficient scientific data backing them, so standard chemotherapy remains the primary reliance. What is showing real results is targeted therapy and immunotherapy, where survival has improved and recurrences and side effects have reduced. Cost has been a sore point since these are expensive medicines, but with generic versions now available and patient assistance programmes extending to international patients, these costs are coming down.
What warning signs alongside hoarseness suggest cancer rather than a benign cause?▼
A tobacco history, age over 45, recent loosening of teeth, an unexplained neck lump, unexplained oral ulceration, a lump in the lip or oral cavity, or red or white patches in the mouth.
What options exist for a patient who has lost his voice after laryngeal cancer surgery and does not want another invasive procedure?▼
An electrolarynx is a non-invasive option: an external prosthesis attached to the skin that creates vibrations at high speed, allowing the patient to vocalise, though the resulting voice is more mechanical than a surgically placed voice prosthesis.
In This Series: When to Suspect Cancer and How to Refer
- 1.When to Suspect Cancer and How to Refer
- 2.Breast Lump Assessment: Why Triple Assessment Comes Before a Diagnosis
- 3.Breast Cancer Screening: Mammography Guidelines and How to Prepare Patients
- 4.Persistent Hoarseness and Laryngeal Cancer: Warning Signs and Voice Rehabilitation
- 5.Persistent Cough and Lung Cancer: Warning Signs and Low-Dose CT Screening
- 6.Abdominal Bloating and Ovarian Cancer: Warning Signs and the Role of CA-125
- 7.Abnormal Vaginal Bleeding: Endometrial Cancer, Cervical Cancer and HPV Vaccination
- 8.Bowel Habit Changes and Colorectal Cancer: Colonoscopy Screening Guidelines
- 9.Common Myths About Cancer Diagnosis and Treatment
- 10.Cancer of Unknown Primary: How Doctors Find the Source