Obstetrics & GynaecologyDr. Supriya MalhotraUterine Fibroids

Obstetrician & Gynaecologist, Fortis La Femme, New Delhi

Part 4 of 9 in Prevalence, Symptoms, Diagnosis and Treatment of Uterine Fibroids

How Uterine Fibroids Are Diagnosed

December 14, 2025

A uterine fibroid can often be suspected on a simple pelvic examination: a bimanual exam may reveal an irregularly enlarged uterus if the fibroid is large enough, though small fibroids are rarely felt this way.

Ultrasound as the first-line test

Once a fibroid is suspected, ultrasound is the first-line investigation and is usually conclusive: fibroids have a distinctive, well-encapsulated, whorled appearance that is rarely missed. Ultrasound also identifies the exact location of a fibroid, which shapes the treatment discussion that follows.

MRI, hysteroscopy and laparoscopy

MRI is reserved for cases needing more detailed mapping, particularly when there is any diagnostic doubt on ultrasound, such as the rare possibility of a cancerous change, since it gives very fine-slice imaging of the tissue and surrounding structures without radiation. Hysteroscopy and laparoscopy are not used as first-line diagnostic tools; they are invasive procedures reserved for situations where a fibroid is found or treated during a procedure done for another reason, or where a submucosal fibroid inside the cavity needs to be visualised and removed directly.

This article is based on a Jivo Masterclass session conducted by Dr. Supriya Malhotra, Obstetrician & Gynaecologist, Fortis La Femme, New Delhi. The article has been summarised with the assistance of an AI tool from the original masterclass recording. Watch the full Masterclass recording

Looking for a diagnosis or a second opinion on uterine fibroids? Get in touch with the Jivo team

This guide is based on a live Jivo Masterclass — Dr. Supriya Malhotra taught doctors across Africa on December 14, 2025.

FROM THE LIVE Q&A

DR

Dr. Inosili (Kenya)

What are the benefits of GnRH analogues in treating fibroids?

SM

Dr. Supriya Malhotra

GnRH analogues are used to shrink a fibroid before a planned myomectomy, since a smaller fibroid means less bleeding during surgery; a monthly or three-monthly dose is given for this. The second use is in a perimenopausal woman, where these hormones hasten the natural shrinkage that would occur anyway as menopause approaches, since fibroids are otherwise known to delay menopause.

See all 12 questions from this masterclass →

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Frequently Asked Questions

At what stage should hysteroscopy be used instead of MRI?

The two are not alternatives for diagnosis. MRI is a radiological procedure with no radiation that gives a detailed, thin-sliced view of a fibroid, and it is used when there is diagnostic doubt on ultrasound, for instance the rare possibility of a cancerous change. Hysteroscopy is a minimally invasive endoscopic procedure passed through the cervix, and it is never used as an investigative tool for diagnosing a fibroid. It is a treatment modality: it is used once a fibroid or polyp inside the cavity has already been identified, so it can be removed under direct vision.

What is your perspective on meat consumption versus a plant-based diet in managing uterine fibroids?

Weight control through exercise and diet is important, since fibroids are more common in obese patients. An anti-inflammatory, broadly Mediterranean diet is recommended: plenty of green leafy vegetables, omega-3 sources like walnuts, flax seeds and olive oil, and less caffeine, alcohol and smoking. Red meat is considered inflammatory, so white meat such as fish, turkey and chicken is the better choice.

How does uterine artery embolization compare with myomectomy?

Myomectomy is a surgical procedure requiring hospitalization, done by a gynaecologist through open surgery, laparoscopy or robotically. Uterine artery embolization is an outpatient procedure done by an interventional radiologist together with a gynaecologist, who passes a catheter through the groin artery into the vessel feeding the fibroid and injects small particles to cut off its blood supply, so the fibroid shrinks over time. It is less invasive and generally preferable to myomectomy, but it has limitations: it is not suitable for very large fibroids, for fibroids with any suspicion of malignancy, or where there is an active uterine infection.

Is hysterectomy the best option for a woman who has completed her family, and are there side effects afterward?

Yes, hysterectomy is a good option for a woman over 40 who has completed childbearing and wants to be free of ongoing fibroid symptoms and medication. If she is under 50 and the ovaries are healthy, they are usually left in place; if she is over 50, the ovaries are usually removed as well. If healthy ovaries are removed before the natural age of menopause, hormone replacement therapy is given until the patient reaches the normal menopausal age, to avoid the more severe mood swings, hot flushes, breast pain and anxiety that a sudden surgical menopause can cause compared with a natural one.

Is there any possibility of targeted gene therapy for fibroids, and how do you see the future of blocking the hormones that drive their growth?

There is a genetic predisposition, but no definitive targeted gene therapy exists yet, largely because the exact cause is still not fully known beyond the working assumption that estrogen and progesterone drive growth, based on the fact that fibroids shrink after menopause. On blocking hormones, this is already happening in a milder form: oral contraceptive pills, which many women take from their late teens into their mid-thirties, work by suppressing internal hormone production, and are safe as long as the patient does not smoke and has no family history of stroke or hypertension.

What is the first test used to diagnose uterine fibroids?

Ultrasound is the first-line test. Fibroids have a distinctive, well-encapsulated, whorled appearance on ultrasound that is rarely missed, and it also shows the fibroid's exact location.

When is MRI needed for uterine fibroids?

MRI is used when there is diagnostic doubt on ultrasound, such as the rare possibility of a cancerous change, since it provides more detailed, fine-slice imaging of the fibroid and surrounding structures.

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