Thoracic SurgeryDr. Shaiwal KhandelwalThoracic Surgery

Director, Thoracic Surgery, Max Healthcare (Saket, Gurugram)

Part 4 of 9 in Thoracic Surgery: Basics to Robotics

Diagnosing and Treating Mediastinal Masses: EBUS, Mediastinoscopy and Thymectomy

August 24, 2025

For undiagnosed mediastinal lymphadenopathy, EBUS (endobronchial ultrasound) is the best first-line diagnostic modality; when it's inconclusive, a VATS mediastinal lymph node biopsy can address all ipsilateral mediastinal nodes and remove the whole lymph node packet for pathology. Video mediastinoscopy, a small neck incision allowing bilateral sampling of the upper and lower paratracheal and subcarinal nodes, is a same-day procedure that reliably yields a diagnosis.

Thymectomy: an increasingly minimally invasive approach

For myasthenia gravis, whether or not a thymoma is present, radical thymectomy removes the whole thymus gland along with all pericardial fat from the neck to the diaphragm, between the two phrenic nerves. This is performed by VATS from both sides, or increasingly through a subxiphoid robotic approach below the sternum, which visualises both phrenic nerves simultaneously and the neck clearly, enhancing both the radicality and safety of the procedure.

Other mediastinal conditions treated minimally invasively

Mediastinal parathyroid adenomas, bronchogenic and oesophageal duplication cysts, oesophageal leiomyoma of any size, and posterior mediastinal neurogenic tumours are all addressed by VATS or robotics. A 12 cm neurogenic tumour just above the diaphragm, deriving its blood supply from the intercostal vessels and encasing the azygos vein, required a segmental azygos resection but was still completed through this minimally invasive approach. Thoracic outlet tumours closely abutting the subclavian vessels are a particularly good fit for robotic surgery, given the precision required in that delicate space; one such high-grade sympathetic chain tumour from a patient referred from Singapore was completely resected with clear margins in a 15-20 minute procedure, with discharge the next day.

This article is based on a Jivo Masterclass session conducted by Dr. Shaiwal Khandelwal, Director, Thoracic Surgery, Max Healthcare. The article has been summarised with the assistance of an AI tool from the original masterclass recording. Watch the full Masterclass recording

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This guide is based on a live Jivo Masterclass — Dr. Shaiwal Khandelwal taught doctors across Africa on August 24, 2025.

FROM THE LIVE Q&A

DR

Dr. Isaya (Nigeria)

Is it possible to invent artificial lungs, and is there any research going on for this? Also, how far away is xenotransplantation, using organs harvested from animals?

SK

Dr. Shaiwal Khandelwal

Devices like Novalung or ECMO are sometimes loosely called artificial lungs, but these are only a transition to tide a patient over, not a permanent solution. Xenotransplantation for lungs is not a reality and is still limited to animal labs, with no near-term prospect of harvesting an animal lung for human transplantation. What is genuinely advancing is ex vivo lung perfusion (EVLP), where a harvested lung is brought to a lab and optimised before transplant, this has meaningfully increased organ utilisation and allows transplant surgery to be done electively rather than only at odd hours, though it remains expensive even in Western countries.

See all 8 questions from this masterclass →

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Frequently Asked Questions

For doctors practising in resource-constrained settings, what is the trigger or the symptom threshold that should tell them a case is complex enough that it may need to be referred abroad, even if they aren't fully sure and want to check first?

Technology has made the world smaller, so practically everyone is living next door to expertise now. Any case can be raised by email or WhatsApp, with a response guaranteed within 24 hours, and the case can often be investigated or even treated locally with guidance if the necessary technology and facilities are available there. When the expertise or facilities are genuinely not available locally, the patient can then be brought to India, but sharing the case first, even just to check whether it meets the threshold for referral, is always the right first step.

Would it be possible to run occasional medical camps where you come to Africa and perform specialist surgeries there directly?

Surgery isn't just about surgeon skill, it also depends on OT infrastructure and trained technical staff, and not everything required can be exported to run a camp abroad. A more practical model already in use is a structured online OPD: patient details and reports are shared in advance on an agreed schedule, and the African doctor partner, the Jivo team, and the Indian specialist jointly review the case and decide what can be treated locally versus what genuinely needs travel to India, with real patient satisfaction from this approach so far.

Approximately how many thoracic surgery patients from Africa have you treated, given that you practise in New Delhi?

A large number of patients from various African countries have been treated, most commonly for bronchiectasis and various tumours of the lung and chest cavity, even without ever having personally visited Africa. For heart transplantation specifically, deceased-donor transplant is not possible for international patients under Indian law, so the more common referral for advanced heart failure from abroad is for an LVAD (left ventricular assist device), which has very good outcomes and has itself reduced overall demand for heart transplant.

What are the success rates of lung transplantation?

Deceased-donor lung transplantation is not possible for international patients in India under current law, but in general, outcomes vary significantly by the underlying pathology, results are good for pulmonary hypertension, while outcomes for cystic fibrosis, bronchiectasis and other conditions vary by the individual disease process rather than following one single success rate.

How do you control fibrosis, meaning adhesions in the lung, following resection of empyema, and is lung transplantation possible after pulmonary tuberculosis?

After empyema surgery in young patients, both a visceral and parietal decortication are performed, and dense adhesions do form afterward, that is simply the nature of the disease and the aim of surgery is to release the lung and prevent fibrothorax, not to avoid adhesions altogether. Lung transplantation after pulmonary tuberculosis is very challenging, particularly if the patient has already developed fibrothorax; a unilateral transplant may be possible in some cases, but it depends entirely on the individual patient and no generalised statement can be made. Deceased-donor lung transplant is also not available to international patients under Indian law, which permits only living donors.

What is the first-line diagnostic test for undiagnosed mediastinal lymphadenopathy?

EBUS (endobronchial ultrasound). If it is inconclusive, a VATS mediastinal lymph node biopsy or video mediastinoscopy can sample or remove the nodes for a definitive pathology diagnosis.

What is the subxiphoid robotic approach to thymectomy?

A robotic technique entering below the sternum through the subxiphoid space, which visualises both phrenic nerves and the neck simultaneously, enhancing the radicality and safety of thymectomy compared to older approaches.

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