Advancements in Infertility Treatment: Regenerative Options for Difficult Cases

Infertility treatment continues to evolve beyond hormone therapy, surgery and assisted reproduction such as IVF. For patients who do not respond to standard treatments, researchers are studying regenerative therapies that aim to repair reproductive tissues rather than only support conception.

Early studies are investigating whether stem cell therapy can improve ovarian function in women with very low egg reserve or early ovarian failure, and whether exosome-based treatments can improve a thin or scarred womb lining. Results so far come from small studies, and these treatments are experimental: international fertility guidelines, including ESHRE's, do not recommend them outside clinical trials.

For patients with complex infertility, established options such as IVF, including with donor eggs, remain the proven treatments. Regenerative therapies may add to these in the future once larger trials show whether they are safe and effective.