CardiologyDr. Biswarup PurkayasthaCoronary Artery Disease

Consultant - Heart & Lung Transplant and Vascular Surgery, Artemis Hospitals, Gurgaon

Part 3 of 12 in Diagnosis & Management of Coronary Artery Disease

How Heart Attack Symptoms Differ Between Men and Women

November 30, 2025

A heart attack does not present identically across patients, and Dr. Biswarup Purkayastha's masterclass opened with the sex-based difference because it is one general practitioners are most likely to misread. Women having a myocardial infarction classically describe jaw pain, some shortness of breath, backache and extreme fatigue, sometimes with nausea and vomiting. Men more often report sweating and a heartburn-like sensation in the chest, which is frequently mistaken for esophageal reflux disease and treated with antacids rather than investigated as a cardiac event.

The general onset pattern

Beyond the sex-specific differences, Purkayastha described a broader symptom cluster common to acute coronary events: heaviness in the chest, cold and sweaty extremities, pain radiating down the left arm from the shoulder, and a sudden feeling of extreme nausea. Onset is often abrupt, in the middle of an ordinary activity, a meeting, a walk, and the patient becomes suddenly short of breath, sweaty, nauseated and exhausted. This presentation, he noted, is more typical in patients over the age of 40.

Two groups that present differently, and why that matters

Purkayastha singled out two patient groups whose presentation deviates from this classic picture: diabetics and women. Diabetics, discussed in more detail elsewhere in this series, often have less pain due to autonomic nerve involvement and can be under-triaged as a result. Women, particularly after menopause, tend to have a longer, softer presentation, sometimes describing symptoms that read as a flu-like illness or mild indigestion rather than an emergency. Purkayastha's point for general practitioners is procedural rather than academic: a woman describing several days of a mild but persistent chest or flu-like complaint, who is still ambulatory and has not collapsed, is not evidence against a cardiac cause. His guidance is to treat it as a myocardial infarction in evolution until proven otherwise, with immediate ECG, bloods and a troponin test, rather than defaulting to a benign explanation because the presentation is soft.

This guide is based on a live Jivo Masterclass — Dr. Biswarup Purkayastha taught doctors across Africa on November 30, 2025.

FROM THE LIVE Q&A

DR

Dr. Boris Pachinko (general practitioner, Zambia)

What about the RFCL, risk factor weighted clinical likelihood, score? It placed this same patient at 10 percent.

BP

Dr. Biswarup Purkayastha

RFCL is an old scoring system we do not use anymore; it produces more false negatives than anything useful. Score this patient with a EuroSCORE now, and a SYNTAX score once an angiogram is available.

See all 10 questions from this masterclass →

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Frequently Asked Questions

Can you say more about coronary artery disease in menopausal women, and about the sympathetic nerve involvement you mentioned in diabetics?

Before 45, women have high estrogen and regular cycles, giving them roughly one-eighth the coronary risk of a man. After menopause, that risk is still about half of a man's, but it rises four-fold from her own prior baseline. The presentation also changes: expect a longer course, days rather than hours, with softer symptoms, a flu-like feeling or mild chest tightness, that get mistaken for a common cold. The best test in this group is a CT coronary angiogram, because women tend to have a lower coronary calcium load, which gives CT angiography a strong positive predictive value for them specifically. Diabetics have a parallel but distinct problem: autonomic nerve involvement blunts the pain signal, so they report less chest pain for the same severity of disease while still showing the nausea, fatigue and cold extremities of an infarction. Physicians need to actively look for the disease in diabetics rather than wait for classic pain.

How do you manage an angina case in a patient who is HIV positive?

The same as anyone else. He gets a coronary angiogram under a universal precautions pathway, and if he has coronary artery disease, it is stentable or operable exactly as it would be otherwise. Any JCI-accredited hospital, ours included, has a protocol to isolate and properly treat these patients. People living with HIV are not discriminated against in access to stenting or bypass surgery.

Is there a direct relationship between pectoralis muscle spasm and coronary artery disease, and if so, what is the first-choice management?

The two are differentiated by troponin: a pectoralis muscle spasm will always return a negative troponin test. There is not really a single first-choice management for a direct link between the two, because they do not co-occur as one diagnosis; one patient might have non-cardiac chest pain from a muscle spasm and separately have coronary disease. Treat each on its own terms: non-steroidal anti-inflammatory drugs for the muscle spasm, and the angiography pathway, deciding between angioplasty and bypass, if there is genuine coronary disease.

Can you explain the relationship between optimal nutrition and coronary artery disease risk?

Optimal nutrition means a high-protein, high-fiber, low-fat, low-carbohydrate diet. Combined with the rest of the prevention checklist, no smoking, more than two hours of exercise a week, regular stress management, and routine blood work from age 40 onward, this kind of consistent lifestyle management can prevent coronary artery disease from progressing to the point of needing an intervention in roughly 80 percent of patients.

A 70-year-old diabetic patient with end-stage renal disease, on hemodialysis for three and a half years, on aspirin and atorvastatin, is admitted with intermittent chest pain and a diagnosis of NSTEMI. What should be the next steps?

Start with single antiplatelet therapy, aspirin, and unfractionated heparin rather than low molecular weight heparin, which recirculates in patients with compromised renal clearance. Dose the heparin roughly three times a day for about two weeks to get him through the acute crisis. Once his symptoms settle and he has had his dialysis, plan a coronary angiogram to decide between stenting and bypass. In a frail, elderly diabetic dialysis patient like this, stenting is usually the better option: it buys time with a much shorter recovery than an operation he may not tolerate well.

How do heart attack symptoms typically differ between men and women?

Women classically describe jaw pain, some shortness of breath, backache and extreme fatigue, sometimes with nausea and vomiting. Men more often report sweating and a heartburn-like chest sensation that gets mistaken for reflux disease.

What is the classic symptom cluster of an acute coronary event?

Heaviness in the chest, cold and sweaty extremities, pain radiating down the left arm from the shoulder, and sudden extreme nausea. Onset is often abrupt, in the middle of an ordinary activity, and is more typical in patients over 40.

Why might a woman's heart attack go unrecognized for several days?

Women can present with a longer, softer symptom course that reads as a flu-like illness or mild indigestion rather than an emergency. The guidance is to treat it as a myocardial infarction in evolution until proven otherwise, with immediate ECG, bloods and a troponin test.

Which patient groups are most likely to have an atypical heart attack presentation?

Diabetics, who often have less pain due to autonomic nerve involvement, and women, particularly after menopause, who tend toward a longer and softer symptom course than the classic presentation.

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