Cardiothoracic & Transplant SurgeryDr. Biswarup PurkayasthaHeart Failure & Coronary Artery Disease

Consultant - Heart & Lung Transplant and Vascular Surgery, Artemis Hospitals, Gurgaon

Part 8 of 14 in All About Heart Failure & Coronary Artery Disease in African Population: The Way Forward

Recognising a Heart Attack: Why Symptoms Differ in Women and Diabetics

June 28, 2026

In men, a myocardial infarction typically presents with the pattern most people expect: heavy, painful chest tightness, cold sweaty skin, pain radiating to the neck or left arm, sudden nausea, sudden breathlessness and extreme fatigue. In women and in diabetics, Dr. Purkayastha stresses, the presentation is far more subtle, closer to a flu-like illness, mild fever, indigestion or acid reflux, sometimes building subacutely over several days and frequently mistaken for heartburn rather than a coronary event.

This gap in presentation is exactly why a much higher index of suspicion has to be maintained for women and diabetic patients specifically: the same underlying event, showing up in a way that a standard symptom checklist will miss.

This guide is based on a live Jivo Masterclass — Dr. Biswarup Purkayastha taught doctors across Africa on June 28, 2026.

FROM THE LIVE Q&A

HO

Host (Varun, Jivo Healthcare)

Can LVADs replace heart transplantation altogether? What is the future of this space?

BP

Dr. Biswarup Purkayastha

For patients above 55, LVADs have to a reasonable extent already replaced transplantation as destination therapy — they can run fifteen years without complications on antiplatelet and anticoagulant therapy alone, with no immunosuppression needed. Three developments will transform deceased-donor transplant over the next decade: donation after circulatory death, which could roughly double the donor pool; ex vivo machine perfusion devices like the TransMedics Organ Care System, which keep a donor heart beating outside the body for twelve to twenty-four hours or more, making cross-continental transport feasible; and xenotransplantation, with genetically modified pig hearts already transplanted into two human recipients. It's unlikely any engineered device will fully replicate a natural heart, though — transplantation will stay relevant for at least the next fifteen to twenty-five years.

See all 9 questions from this masterclass →

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Frequently Asked Questions

What is the best approach to managing peripheral oedema — swelling of the feet — in a patient with HIV, pulmonary tuberculosis, and hypotension?

The first step is an urgent echocardiogram to establish ejection fraction precisely using Simpson's biplane method — the clinical picture at 35% and at 20% are entirely different territories. Below 20%, options are very limited; diuretics alone won't fully resolve the oedema. The Aquadex SmartFlow ultrafiltration system, with a 15ml prime volume removing 60 to 100ml of fluid per hour, is the logical next step when diuretics are failing. But with ejection fraction below 20% in the context of HIV and TB, and hypotension further constraining options, the situation is close to endgame — peritoneal dialysis is theoretically possible, but introducing a device into the body cavity of a patient with active communicable disease carries an infection risk that makes it unsafe in most circumstances.

Regarding valve repair strategies in heart failure, specifically a tricuspid valve case where the options are mechanical valve, bioprosthetic valve, or transcatheter edge-to-edge repair (TEER) — which is preferred and when?

The tricuspid valve is more often repaired than replaced. Even in a moderately aged patient in the 50 to 60 age group, if tricuspid valve replacement is necessary, a bioprosthetic valve is preferable to a mechanical valve — the right side is a low-pressure circuit, so a mechanical valve there carries a very high thrombosis risk that can embolise to the lung and be fatal. The preferred approach overall is tricuspid repair, either a traditional DeVega repair or an annuloplasty ring. TEER (TriClip for the tricuspid, MitraClip for the mitral) warrants real caution — for the mitral valve it's the surgical community's last resort, used only when every other repair technique and replacement are precluded by financial or anatomical constraint. With today's preoperative 3D imaging of the mitral annulus, a surgeon can nearly always plan intervention in advance instead.

What is the role of traditional alcohol in cardiomyopathy?

The evidence is unambiguous: any form of alcohol predisposes to cardiac dysfunction. Traditional drinks have been examined alongside commercially available alcohol in studies, and the myth that red wine protects the heart has been comprehensively debunked. Chronic alcohol consumption damages the heart, full stop. Whether someone chooses to drink socially is a personal decision, but scientifically there is no basis for recommending any alcohol for cardiac health.

How do you manage the bleeding risk when loading a patient with 600mg aspirin and clopidogrel?

You do not manage it — you accept it, because that is your best option to open the coronary artery blockage. The bleeding risk is only a problem in a living patient. If the patient dies from a myocardial infarction for lack of intervention, there is no bleeding to manage.

What is the primary indication for using sacubitril/valsartan, and how is it dosed?

It should be started at the lowest possible dose — half a tablet, 25mg once daily, titrated over a week to 50mg, then 100mg, not typically exceeding 100mg once daily or 50mg twice daily. The primary indication is ejection fraction below 45% with elevated NT-proBNP. In a patient with ejection fraction below 35% and high NT-proBNP, it should be initiated at the lowest dose and titrated carefully upward.

What are the classic symptoms of a heart attack in men?

Heavy, painful chest tightness, cold sweaty skin, pain radiating to the neck or left arm, sudden nausea, sudden breathlessness, and extreme fatigue.

Why are heart attacks harder to recognise in women and diabetic patients?

Because the presentation is far more subtle, closer to a flu-like illness, mild fever, indigestion or acid reflux, sometimes building subacutely over several days and frequently mistaken for heartburn.

What should clinicians do differently when assessing women or diabetic patients for cardiac events?

Maintain a much higher index of suspicion, since the same underlying event can present in a way that a standard symptom checklist will miss entirely.

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