Chief, Pain Medicine & Palliative Care, Artemis Hospitals, Gurgaon, India
Part 4 of 13 in Advances in Chronic Pain Treatment: The Latest Trends
Sphenopalatine Ganglion Block: Cluster Headache, Migraine and Burning Mouth Syndrome
July 12, 2026
The sphenopalatine ganglion sits deep in the pterygopalatine fossa at the base of the skull, and blocking or ablating it is Dr. Jain's answer for cluster headache that hasn't responded to medical management, migraine, and atypical facial pain, particularly burning mouth syndrome, where patients feel a persistent burning sensation on the tongue and in the mouth.
He describes treating a 27-year-old patient from Oman with severe bilateral burning mouth syndrome in a single sitting, needles placed on both sides of the face under fluoroscopic guidance, the whole procedure taking about an hour. The patient, he says, was completely well afterward: a case from before the COVID-19 pandemic that he still references for how disabling and treatable this condition can be.
This guide is based on a live Jivo Masterclass — Dr. Ashu Kumar Jain taught doctors across Africa on July 12, 2026.
FROM THE LIVE Q&A
Dr. Ivan, Uganda
What are the most common misconceptions community doctors have about facet joint injection?
Dr. Ashu Kumar Jain
The first issue is simply diagnosis — ninety per cent of doctors not trained for this kind of spinal pain can't diagnose facetogenic pain. We call it axial pain, which includes facetogenic and discogenic pain, and gabapentinoids are of no use for it whatsoever — yet eight out of ten patients with axial pain are given these drugs with no results. It's a diagnostic challenge first: specific questions in the history, a specific examination, then a diagnostic block to confirm the pain is coming from the facet before proceeding to facet joint RFA.
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Frequently Asked Questions
Bone marrow transplant is a cure for sickle cell disease but isn't offered to every patient, including for cost reasons. How can sickle cell patients with chronic pain from avascular necrosis of the femoral head benefit?▼
If the femoral head is involved, we can perform radiofrequency ablation of the hip joint, ablating the articular nerves supplying the joint — it's a very rewarding procedure. But if the pain is arising from the bone itself or visceral involvement, the best approach is opioid analgesics rather than high-dose NSAIDs, which will damage the kidneys. Primary management is opioid-based — morphine or tramadol with paracetamol and a neuropathic agent — and where there is a specific anatomical target, we address that interventionally as well.
Quite often a patient presents in pain and there's a surgical solution, and sometimes it falls in your domain where surgery isn't required. How do physicians decide when a patient should go for surgery versus pain management?▼
According to international Spine Society guidelines, any pain coming from the spine where the primary problem is pain alone does not require surgery. The indications for surgery are disability — foot drop, motor or sensory deficit — or more than moderate to severe canal stenosis on MRI, where pain intervention can buy time but can't treat the disease. If a patient comes to me with a neurological deficit, I immediately refer to the spine surgeon and don't proceed with intervention. If pain is the only presenting symptom, we treat it — there's a very clear demarcation.
The concern with opioids for conditions like avascular necrosis is that they can be habit-forming or cause addiction — can you address that?▼
If you use opioids for chronic low back pain, knee pain or musculoskeletal pain, yes, they are habit-forming. But for cancer pain, and for pain like sickle cell disease — which we manage on the same lines as cancer pain — they are never habit-forming. Visceral pain is mediated by the sympathetic nervous system and doesn't respond to conventional NSAIDs, so it needs neuropathic agents and opioids in combination; back pain, knee pain and shoulder pain are peripheral musculoskeletal or neuropathic pain and don't carry the same opioid receptor expression, which is why the risk profile is so different between the two.
In RFA, can the treated nerves regenerate? And if so, when can pain reoccur?▼
The nerve cannot truly regenerate in the clinical sense. When there is nerve injury, the patient can go into complex regional pain syndrome Type II. Nerve regeneration takes a very long time and the results are poor — if you believe you can treat a patient through nerve regeneration, in present-day practice that is a myth.
Which local anaesthetics, steroids and adjuvants do you usually use for different nerve blocks?▼
For nerve blocks we use ropivacaine. For steroids, we primarily use dexamethasone in spinal procedures. For joint injections, we usually use Kenacort (triamcinolone).
What is the sphenopalatine ganglion, and what conditions can blocking it treat?▼
It sits deep in the pterygopalatine fossa at the base of the skull. Blocking or ablating it treats cluster headache that has not responded to medical management, migraine, and atypical facial pain, particularly burning mouth syndrome.
What is burning mouth syndrome?▼
A condition in which patients feel a persistent burning sensation on the tongue and in the mouth, which can be severe and disabling.
Can burning mouth syndrome be treated in a single session?▼
Yes. A 27-year-old patient from Oman with severe bilateral burning mouth syndrome was treated in a single sitting, with needles placed on both sides of the face under fluoroscopic guidance over about an hour, and was completely well afterward.
In This Series: Advances in Chronic Pain Treatment: The Latest Trends
- 1.Advances in Chronic Pain Treatment
- 2.Trigeminal Neuralgia: Radiofrequency Ablation vs Surgery
- 3.Cervicogenic Headache: When Neck Problems Cause Migraines
- 4.Sphenopalatine Ganglion Block: Cluster Headache, Migraine and Burning Mouth Syndrome
- 5.Cervical Radiculopathy: Why Most Neck-Related Arm Pain Doesn't Need Surgery
- 6.T2-T3 Sympathectomy for Complex Regional Pain Syndrome
- 7.Shoulder Pain Without Surgery: Adhesive Capsulitis and the 3-in-1 Block
- 8.Sciatica and Failed Back Surgery: Transforaminal Epidural Adhesiolysis
- 9.Discogenic Back Pain: Biacuplasty and Finding the Painful Disc
- 10.Cancer Pain Management: Sympathetic Nerve Blocks for Pelvic and Upper GI Cancer
- 11.Coccydynia and Pelvic Pain: Ganglion Impar and Pudendal Nerve Blocks
- 12.Knee Pain and Spinal Cord Stimulation: Advanced Options When Surgery Isn't Right
- 13.Opioids in Chronic Pain: When They're Safe, When They're Not