CardiologyDr. Aseem R. SrivastavaCongenital Heart Disease

Chief - Paediatric Cardio Thoracic and Vascular Surgery (CTVS), Artemis Hospitals, Gurgaon, India

Part 14 of 14 in Correct Timing for Congenital Heart Surgery

Ventricular Septal Defect (VSD): When Small Holes Close on Their Own and When Surgery Can't Wait

August 6, 2026

A large ventricular septal defect should be closed at 6 to 12 months of age, since around 9 to 10 percent of children with a large, untreated VSD die by their first birthday, while small VSDs usually close on their own and need no surgery at all.

Why VSD size determines the approach

A ventricular septal defect, or VSD, is a communication between the right and left ventricles of the heart. The chance of a VSD closing on its own is inversely related to its size: small VSDs, which make up the largest proportion of cases, close spontaneously in around 80 percent of children and rarely need treatment. Larger VSDs are far less likely to close on their own, and the risk of death from a VSD rises directly with its size, so waiting for spontaneous closure of a large VSD is never recommended.

Timing surgery for moderate and large VSDs

Moderate VSDs cause heart failure symptoms that can usually be managed with medication, and in these children waiting for one to two years is acceptable. Large VSDs carry a mortality risk of about 9 to 10 percent by one year of age if untreated, so the recommended age for VSD closure in these children is 6 to 12 months, unless heart failure symptoms cannot be controlled with medications such as furosemide, spironolactone and digoxin, in which case surgery is recommended immediately, even in a newborn as young as 15 days to 2 months old.

Why earlier repair gives a better surgical cure

A successful outcome for VSD closure is defined as the child being alive long term with near-normal pulmonary artery pressure. If the VSD is repaired at 6 months of age, the chance of this kind of surgical cure is 95 percent or more, but a true surgical cure becomes rare if VSD closure is delayed until 4 years of age. This is why 6 to 12 months is the recommended window for closing a large VSD.

← Atrial Septal Defect (ASD): Why the Best Age to Close It Is 3 to 4 Years | Series index | AV Canal Defect: Why Surgery Is Needed by 3 to 4 Months of Age →

This article is based on a Jivo Masterclass session conducted by Dr. Aseem R. Srivastava, Chief, Paediatric CTVS and Adult Congenital Heart Diseases, Artemis Hospitals, Gurgaon, India. The article has been summarised with the assistance of an AI tool from the original masterclass recording. Watch the full Masterclass recording

This guide is based on a live Jivo Masterclass — Dr. Aseem R. Srivastava taught doctors across Africa on August 31, 2025.

FROM THE LIVE Q&A

DR

Dr. William Gataga (Zimbabwe)

What is the average cost of ASD closure?

AR

Dr. Aseem R. Srivastava

Approximately 5,500 USD.

See all 2 questions from this masterclass →

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Frequently Asked Questions

What is the correct timing for a patient with transposition of the great arteries (TGA), VSD, and LVOT obstruction? Also, since we live in a resource-limited country where diagnosis is sometimes made late, and patients may then ask for treatment abroad after a late diagnosis, what is your recommendation for handling late presenters, especially with simple shunt lesions?

For TGA with VSD and LVOT obstruction, these kids essentially have pulmonary stenosis with a VSD, and timing depends on the kid's oxygen saturation — they will need a Rastelli or a Nikaidoh operation, both requiring an implant, and the intent is to give the biggest implant possible since a smaller implant means an earlier return for a change. If saturations are above 75% and the kid is growing and doing well, they can wait and have surgery at around one year of age; if saturations are less than 75% with significant failure to thrive, they should come for surgery at any age or weight. On late presenters: we are also a resource-limited country — four or five surgeons doing this work for half of India — and face the same problem of kids coming late every day. My suggestion is education programmes, including pulse oximeter screening at birth, 1 month, and 6 months, referring for an echo early if abnormal. Late-presenting PDAs and cyanotic conditions apart from TGA are usually still operable, even if at slightly higher risk, but VSD shunt lesions can become inoperable if too late — however, even when a kid looks clinically inoperable, we always offer a cardiac catheterisation to confirm, since a significant proportion will still turn out to be operable, if high risk. And even an inoperable VSD child, with good, appropriately timed medical management (diuretics, pulmonary vasodilators), can still survive 25–35 years, whereas without that care they will die much earlier.

What is the average cost of ASD closure?

Approximately 5,500 USD.

Do all ventricular septal defects need surgery?

No. Small VSDs, which make up the largest proportion of cases, close spontaneously in around 80 percent of children and rarely need treatment.

When should a large ventricular septal defect be closed?

At 6 to 12 months of age. Around 9 to 10 percent of children with a large, untreated VSD die by their first birthday, so waiting for spontaneous closure is never recommended for large defects.

What if heart failure symptoms from a VSD cannot be controlled with medication?

Surgery is recommended immediately, even in a newborn as young as 15 days to 2 months old, rather than waiting for the standard 6 to 12 month window.

Does the age at VSD repair affect the chance of a full surgical cure?

Yes, significantly. If repaired at 6 months of age, the chance of a surgical cure, meaning the child alive long term with near-normal pulmonary artery pressure, is 95 percent or more, but a true cure becomes rare if closure is delayed until 4 years of age.

Can a moderate VSD wait for surgery?

Yes. Moderate VSDs cause heart failure symptoms that can usually be managed with medication, and in these children waiting one to two years is acceptable.

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