Senior Director, Urology, Uro-Oncology, Andrology and Kidney Transplant, BLK-Max Super Speciality Hospital, New Delhi
Part 9 of 10 in Robotic Radical Prostatectomy: Redefining Precision in Prostate Cancer Surgery
Managing Prostate and Kidney Cancer Without Access to Robotic Surgery
September 13, 2026
Doctors practising where robotic surgery, biopsy or advanced imaging are not routinely available still need a clear framework for managing and referring uro-oncology cases.
Prostate cancer without access to robotic surgery
Where prostate disease is diagnosed on PSA alone (a level above 20 suggestive of cancer, above 35 suggestive of advanced or metastatic disease) without routine biopsy or metastatic work-up, and pelvic surgery is difficult, orchidectomy is sometimes used as the default treatment. For localised disease, orchidectomy should be avoided since it causes more harm than benefit, leaves the patient without erections, and the disease may still progress to bone or elsewhere over time. An MRI of the lumbar spine and pelvis, more widely available than bone or PET scans, can screen for bony metastasis; orchidectomy is justified only once metastasis is confirmed. Otherwise, patients with early-stage disease should be told clearly that definitive treatment is not currently available locally, and referred for treatment abroad, with help arranging financial support and other resources where needed.
Metastatic renal cell carcinoma with an IVC thrombus
In a case of renal cell carcinoma with liver and lung metastases and a thrombus extending from the renal vein into the IVC, a kidney biopsy should ideally establish the histological subtype to guide systemic treatment, using immunotherapies such as nivolumab, or TKIs such as sunitinib or pazopanib if immunotherapy is unavailable. These agents are distinct from chemotherapy, to which renal cell carcinoma is resistant, and immunotherapy is increasingly recommended in guidelines for advanced disease. A patient with liver metastases is not a surgical candidate and needs a realistic prognosis; nephrectomy with IVC thrombectomy remains appropriate when disease is confined to the kidney and IVC, but once there are multiple distant metastases, surgery no longer helps.
This article is based on a Jivo Masterclass session conducted by Dr. Y P S Rana, Director, Urology, Uro-Oncology, Andrology and Kidney Transplant, BLK-Max Super Speciality Hospital, New Delhi. The article has been summarised with the assistance of an AI tool from the original masterclass recording. Watch the full Masterclass recording
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This guide is based on a live Jivo Masterclass: Dr. Yajvender Pratap Singh Rana taught doctors across Africa on September 13, 2026.
FROM THE LIVE Q&A
Moderator
What are the best currently available anti-cancer therapies in India for advanced prostate cancer, and what role do targeted gene therapy and immunotherapy play?
Dr. Yajvender Pratap Singh Rana
The backbone remains continuous ADT, agents like degarelix or leuprolide, combined with newer anti-androgens such as abiraterone or enzalutamide, known as ARPIs (androgen receptor pathway inhibitors), plus genetic testing, where a BRCA mutation supports adding a PARP inhibitor such as olaparib, with many patients now on doublet, triplet or even quadruplet combinations rather than ADT alone. Oligometastatic (limited stage 4) disease confined mainly to the prostate and pelvis can still be surgically debulked alongside roughly one to one-and-a-half years of ADT; widespread stage 4 disease has no surgical indication. When these lines of treatment fail, options include immunotherapy, docetaxel- or paclitaxel-based chemotherapy, and lutetium (PSMA) radioligand therapy, which tags rapidly-dividing, PSMA-expressing tumour cells for targeted internal radiotherapy, plus other immunotherapies such as pembrolizumab. Targeted gene therapy itself isn't yet in commercial clinical use, what is used is genetic testing to select the most effective molecule for a given patient's mutation profile, such as PARP inhibitors for BRCA2-positive cancer.
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Frequently Asked Questions
How should counselling be framed for patients with very advanced prostate cancer?▼
The patient needs a realistic sense of hope appropriate to their stage. A PSA above 1000 indicates metastatic disease, and in that setting the approach shifts from surgical cure to bringing the cancer under control with ADT and other systemic molecules.
How does training for robotic radical prostatectomy work, and is prostatectomy for benign prostate disease also done transurethrally with the robot?▼
Transurethral procedures such as bipolar enucleation, bipolar resection, TURP, or HoLEP are all for benign prostate enlargement. Radical prostatectomy is a different operation for cancer of the prostate, done robotically. There is also a robotic option for very large benign glands: whenever the prostate is bigger than 200 to 250 grams, a robotic simple prostatectomy is performed instead of a transurethral procedure.
Most patients' biggest concern before agreeing to prostatectomy is how well and how quickly they will return to normal erectile function - how should that be addressed?▼
Outcomes vary by patient. In one case, a patient in his early sixties found to have a Gleason 4+4 tumour during routine follow-up for an unrelated condition could not be kept on active surveillance despite being young and sexually active. Given a realistic estimate of about an 80% chance of good erections afterward, he was started on tadalafil to prime the tissue before robotic surgery; within about four weeks of catheter removal he reported a full return of intimacy with his wife. Preservation depends on how sexually active and physically strong the patient was beforehand and on the tumour stage: early-stage tumours allow both neurovascular bundles to be spared, with tadalafil and, if needed, self-stimulation techniques or intracavernosal injections used during rehabilitation; in advanced cases where nerves cannot be spared, a penile implant remains an option. Cancer cure always comes first, since the patient must survive before sexual function can be addressed.
How long does it typically take for erectile function to return to normal after prostatectomy?▼
It varies by surgery, patient and condition, recovery can be as early as 4 to 6 weeks, sometimes 3 months, sometimes a year, and it may or may not return at all, depending on multiple contributing factors. In the prostate cancer trifecta used to counsel patients, cancer control comes first, urinary control second, and sexual control third.
For patients with early-stage, non-locally-advanced prostate cancer, what is the role of ablative or focal therapy such as HIFU (high-intensity focused ultrasound)?▼
Prostate cancer is usually multifocal, so focal therapy only suits a small subset of patients, about 2 to 5% of the whole pool, where a complete systematic biopsy confirms one localised, well-circumscribed nodule with the rest of the gland genuinely tumour-free; this treatment is available in India when that scenario applies. Because most prostate cancer is multifocal, robotic surgery remains the treatment of choice, with a time-proven cure rate of roughly 95%. Focal therapy treats one spot, but a new nodule can appear elsewhere later, and prior radiotherapy or focal therapy makes a subsequent robotic surgery more difficult and reduces the chance of preserving nerves and sexual function, so focal therapy is not an alternative to robotic surgery, just a different treatment for a different kind of patient.
Should orchidectomy be used to treat localised prostate cancer?▼
No - it causes more harm than benefit and leaves the patient without erections, while the disease may still progress; it should only be considered once metastasis is confirmed, for example via a lumbar spine and pelvis MRI where bone or PET scans aren't available.
Can renal cell carcinoma with an IVC thrombus be operated on?▼
Yes, if disease is confined to the kidney and IVC - nephrectomy with IVC thrombectomy is appropriate - but once there are multiple distant metastases, surgery no longer helps and systemic treatment (immunotherapy or TKIs) is the priority.
In This Series: Robotic Radical Prostatectomy: Redefining Precision in Prostate Cancer Surgery
- 1.Robotic Radical Prostatectomy
- 2.Early Warning Signs and Diagnostic Work-Up in Uro-Oncology
- 3.Managing Locally Advanced Prostate Cancer with Neoadjuvant ADT
- 4.Treatment Options for Localised and Locally Advanced Prostate Cancer
- 5.Robotic Radical Prostatectomy: Step-by-Step Surgical Technique
- 6.Erectile Function Recovery After Robotic Prostatectomy
- 7.Focal Therapy (HIFU) vs Robotic Surgery vs Open Surgery
- 8.Robotic Partial Nephrectomy for Kidney Tumours
- 9.Managing Prostate and Kidney Cancer Without Access to Robotic Surgery
- 10.Systemic and Targeted Treatment for Advanced Prostate Cancer