Joint Injections for Arthritis: Hyaluronic Acid, PRP, Stem Cells and Steroids

It's a permanent, non-removable procedure — it doesn't need to be removed. The follow-ups: the first milestone is at two weeks, to remove the stitches, then six weeks post-surgery, then three months, six months, and then annually.

In athletes the demand of activity is much more than the normal population — jumping, contact sports — and there's wear and tear involved in the artificial joint over time. We generally tell patients not to jump or run, for the sake of the longevity of the implant — the more activity, the more wear, and the more chance of needing revision surgery. First we tell them to change their activity level if possible; if that's not possible, there are certain implant variations available, like hip resurfacing or metal-on-metal implants, which can be offered if it's mandatory for the athlete to continue their sport — though ceramic implants are not good for them because of a higher chance of breakage.

For infection: understand the kind and duration of it. If it's acute, be very aggressive — antibiotics alone won't suffice, don't hesitate to go inside and clean the joint, with multiple debridements till it feels clean; antibiotics work as an adjuvant, not the primary therapy. In the knee you can also change the polyethylene component, put a drain for three to five days, give antibiotics. But if it's longstanding — more than a month — you may need staged revision surgery: stage one, remove the implant and put an antibiotic spacer, monitor for six weeks until infection markers are normal and skin has healed, then stage two, the revision total replacement. On MRI: all joint replacements can have an MRI done, provided the implant is well fixed — if it's unstable, MRI may not be a good idea, but if the joint is stable, MRI can be done using implant-specific coils that neutralise the implant artefact.

This is a common perception, actually — in the first six to eight weeks we don't want the patient to bend beyond 90 degrees, talking about hip replacements, to reduce the chances of dislocation so the capsule heals well. That's the 90 degree rule for hip replacement.

KL is just the WHO classification of osteoarthritis — it's not very good. Diagnosis is a clinical one: patients complaining of typical pain — pain while walking, pain while taking stairs, pain while sitting cross-legged — with definitive tenderness on the joint line, is almost confirmatory. That's the real gold standard, not the X-ray. X-ray is the baseline test, but it's not the criterion for deciding which patient should undergo surgery — a grade four KL arthritis patient with minimal pain treated well with physical therapy may not be a candidate for joint replacement, while a grade three patient who has tried all conservative measures without relief could be. It's a paradox, so X-ray grading alone isn't the gold standard. On location: for osteophytes, the location of weight-bearing matters more, but for me it's typically joint space reduction that matters most, because it indirectly shows the articular cartilage is gone — and that's irreversible.

Four main types: hyaluronic acid, platelet-rich plasma, stem cells and corticosteroids, each offering a different balance of speed and duration of relief.

Hyaluronic acid, or viscosupplementation, gives earlier pain relief than PRP or stem cell injections, though it is temporary, typically lasting six months to a year.

Because the fast, strong relief they provide can lead patients to believe they are cured, prompting them to resume high impact activity too soon and accelerate deterioration of the joint. Infection is the main complication to watch for with any joint injection.

Patients with severe osteoarthritis who are not yet fit for surgery, or who are not willing to undergo joint replacement in the near future. Injections buy time and keep the patient functional until surgery becomes necessary.