Chairman, Manipal Institute of Cardiac Sciences & Chief of Clinical Services, Manipal Hospital, Dwarka, New Delhi
Part 3 of 7 in Robotic Assisted Cardiac Surgery
Minimally Invasive and Robotic Valve Repair and Replacement
January 26, 2025
Valve surgery makes up a large share of Dr. Yugal Kishore Mishra's minimally invasive practice at Manipal Hospital. In his Jivo Masterclass, he walked through the actual technique, case by case, for mitral valve repair, mitral valve replacement, and aortic valve replacement through a small port or partial sternotomy instead of a full sternotomy.
Getting Access Without Opening the Chest
For mitral valve surgery, the approach is a fourth intercostal space thoracotomy on the right side, with the patient positioned right-side up. A soft-tissue retractor and then a thoracic retractor create the working space, a cannula delivers CO2 into the field to aid de-airing, and a specially designed instrument known as an L-retractor exposes the valve itself. Femoral artery and vein cannulation, either through an open cutdown or percutaneously, establishes cardiopulmonary bypass, sometimes alongside percutaneous jugular vein cannulation.
Repairing the Mitral Valve
In one case Dr. Mishra showed during the session, a patient had a prolapsing P2 segment, the middle scallop of the posterior mitral leaflet. He excised the diseased P2 segment, reconstructed the leaflet by suturing the remaining segments back together, tested the repair for competency, then implanted a Carpentier-Edwards annuloplasty ring and tested the valve again before closing. Tying knots by hand through a small port incision is difficult, so Manipal Hospital uses an automated suture-fastening device, marketed as Cor-Knot, that ties a secure knot in a fraction of a second, without needing to pass a hand or a knot-pusher through the incision at all.
Replacing the Valve, and What the Replacement Is Made Of
Where the valve is replaced rather than repaired, Dr. Mishra uses a tissue valve, the Mitris valve from Edwards Lifesciences, with an expected lifespan of 15 to 20 years, available for both the mitral and aortic positions. Aortic valve replacement itself is done through an upper partial sternotomy or a right second-intercostal-space thoracotomy: the aorta is exposed, cross-clamped with a specially designed flexible clamp introduced through the same small incision, opened, the calcified native valve removed, and the tissue valve sutured in. Because the working space is shallower for aortic cases, Dr. Mishra ties these knots by hand rather than with the automated device.
How Long a Repair or a Tissue Valve Actually Lasts
Asked directly about recurrence, Dr. Mishra was specific: Cleveland Clinic data shows a meaningful rate of repair failure by 10 years even in purely degenerative valve disease, and the failure rate is higher again specifically in rheumatic valve segments. Tissue valves themselves fail after 10 to 15 years. When that happens in a patient who already has a tissue valve in the aortic or mitral position, a transcatheter, percutaneous TAVI valve-in-valve procedure, without repeat open surgery, is now an option. A failed mechanical valve, whether from a paravalvular leak or thrombus formation, is treated with thrombolysis or, if that fails, re-replacement.
This guide is based on a live Jivo Masterclass: Dr. Yugal Kishore Mishra taught doctors across Africa on January 26, 2025.
FROM THE LIVE Q&A
Dr. Yanik
Are there recurrences after repair and replacement of the valve in a patient who has suffered from valvulopathy?
Dr. Yugal Kishore Mishra
Yes, there is always a possibility of failed repair, so the patient may require re-repair or replacement. Cleveland Clinic data shows that even in degenerative disease there is significant failure of repair after 10 years, and in a rheumatic segment specifically the failure rate is quite a bit higher. When we replace the valve with a tissue valve, we know that after 10 to 15 years tissue valves are going to fail. We now have a percutaneous TAVI valve which can be implanted without surgery if the patient already has a tissue valve in the aortic or mitral position. For a mechanical valve, if there is a failure in the form of a paravalvular leak or thrombus formation, we either do thrombolysis or have to re-replace the mechanical valve.
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Frequently Asked Questions
How can one improve his or her robotic surgery skills?▼
You need hands-on training. I started robotic surgery in India in 2002, the first time in Asia, and since then I have done around 700 robotic surgeries. In India we train people who want to come; I get at least five to ten people a month who come across India and also from other countries to get trained for robotic surgery. Intuitive Surgical, which makes the da Vinci system, was earlier reluctant but has now started looking at training in cardiac surgery. The good news is that we also have an India-made robotic system, SSI Mantra, specially designed for cardiac surgery, which is comparatively cheaper than the Intuitive robot and also best suited for cardiac surgery, and they also train. Countries like Indonesia and the Philippines have now started buying that system too, and in India we have around 25 to 30 systems working.
What type of cardiac surgery is preferred for robotic assistance?▼
What I am doing here is coronary artery bypass surgery, and the job of the robot for coronary artery bypass surgery is to take down the two mammary arteries with the help of the robot and then do the bypass, and direct valve repair and replacement with the robot. We also do atrial septal defect closure and removal of myxomas. Some surgeons have now started doing valve replacement with the robot, but I am not doing that. I'm not comfortable with it.
Is there any age contraindication for minimally invasive cardiac surgery?▼
For young patients, since in minimally invasive surgery we usually cannulate the femoral artery and vein, patients less than six years old have very small femoral arteries, so we avoid the minimal access approach in very young children. After six years, I have done ASD closure in a 7-year-old, putting in a 14 French femoral cannula, so up to about 3.2mm femoral artery size is appropriate for cannulation; less than that is not good. For older patients, the contraindications I already mentioned apply, such as atheromatous changes in the femoral artery, which is not good for cannulation, or changes in the ascending aorta, such as calcification, which is again not a good aorta for this. That's why beforehand we do a Doppler study of the femoral artery and vein to see the size and any lesions, and a CT scan to see the ascending aorta and the tortuosity of the iliac vessels.
How does the cost of minimally invasive and robotic cardiac surgery compare with the affordability of regular surgery?▼
Minimally invasive surgery is definitely costlier than regular surgery because we use specially designed instruments, and robotic surgery is even more costly because the robotic instruments and system are costly. So it's going to be costlier, maybe one and a half times than regular surgery, but you gain more: you can start working in three weeks instead of losing three months, there is less pain, early hospital discharge, less blood loss and less ICU stay. So these are the advantages, but definitely minimally invasive and robotic surgery is more expensive than conventional surgery.
A doctor from Ethiopia thanked Dr. Mishra for his interest in cardiac surgery, noted the shortage of cardiac surgeons in Ethiopia and that most patients cannot afford treatment abroad, and asked whether Dr. Mishra could help him study in India.▼
There are two things: technique and technology. Even though you are trained, you should also have the hardware in your country; a robotic system is very expensive, but I am currently operating on some patients from Ethiopia and they are affording the minimally invasive and robotic surgery they ask for. You are welcome to come and have a short visit, maybe one week, two weeks, three weeks, four weeks, whatever you can manage, and get trained. If you require, we can go and proctor you for a few cases there too. Before that, if you have patients, definitely refer them; you can come with the patient, watch, and that is the way to train. You can't become a minimally invasive or robotic surgeon in day one. Before I started I must have visited 15 countries across Europe and North America to get trained, and then I was proctored by surgeons across the world at some of the best centres. I have done around 3,500 minimally invasive cardiac surgeries and around 7,700 robotic surgeries. We also formed a society, so you can come and participate in our annual meeting. We are going to very soon start a fellowship program through our society, and we can give some financial assistance to people who are interested in this area, though that will be a visiting fellowship for a week or so.
In This Series: Robotic Assisted Cardiac Surgery
- 1.Robotic Assisted Cardiac Surgery
- 2.What Minimally Invasive Cardiac Surgery Actually Means
- 3.Minimally Invasive and Robotic Valve Repair and Replacement
- 4.Robotic and Minimally Invasive Coronary Artery Bypass Surgery
- 5.Who Qualifies for Minimally Invasive Cardiac Surgery
- 6.Recovery, Cost and Outcomes After Minimally Invasive Cardiac Surgery
- 7.Training the Next Generation of Robotic Cardiac Surgeons