Diagnosis and Management of Prostate Cancer

July 7, 2024
Dr. Nitin Shrivastava, Consultant, Urology and Uro-Oncology at Artemis Hospital, Gurgaon, walks through prostate cancer screening, PSA interpretation, biopsy decision-making and BPH management. The extended discussion covers TURP limits, post-surgical incontinence, neobladder reconstruction, and nutrition.
Questions Doctors Asked Dr.Nitin Shrivastava
Real questions from the live masterclass, answered by Dr.Nitin Shrivastava, Urology / Oncology.
What is the value of PSA to say increased in a catheterized old patient, assuming 60 plus?
Asked by Moderator
There is no cut-off value for a catheterized patient. Slight PSA increase is expected, sometimes to 8, 9 or 10, or occasionally near 20. If the PSA remains rising, an MRI should be done to find out what's going on inside the prostate.
Answered by Dr.Nitin Shrivastava
What is the role of physical medicine and rehabilitation in the treatment of prostate cancer?
Asked by Moderator
Rehabilitation does not treat the prostate cancer itself, but it is an integral part of the treatment process. After prostate surgery, patients need to do Kegel exercises to regain continence.
Answered by Dr.Nitin Shrivastava
What factors should we consider when interpreting age-adjusted PSA levels, other than UTI?
Asked by Moderator
The rise in subsequent PSA levels, PSA velocity, and PSA density all give more clues when a reading is borderline, and these additional tests should be done before deciding on a biopsy.
Answered by Dr.Nitin Shrivastava
What is the time range that should be considered between two PSA measurements during screening?
Asked by Moderator
Routine mass PSA screening is not recommended. But for high-risk patients, yearly PSA is a good idea. If the PSA comes out abnormal, it should be repeated after four to six weeks.
Answered by Dr.Nitin Shrivastava
What is the best method of managing BPH?
Asked by Moderator
First make sure BPH is not causing damage to the kidneys. For mild symptoms, only lifestyle management is needed. For bothersome symptoms, a single alpha blocker is used. There is no one universal method; if it's damaging the kidneys, surgery is needed.
Answered by Dr.Nitin Shrivastava
Apart from PSA, what other hormones should be monitored in case of prostate cancer?
Asked by Moderator
None. PSA is the only one.
Answered by Dr.Nitin Shrivastava
What are the factors contributing to prostate cancer, and what are the staging parameters?
Asked by Moderator
The most important contributing factor is genetics and family history. Researchers point to some role of obesity and possibly a non-vegetarian diet, but these risk factors are not firmly established.
Answered by Dr.Nitin Shrivastava
What is a neobladder? What is an ileal conduit? How will treatment affect my quality of life?
Asked by Moderator
Neobladder and ileal conduit are treatments for bladder cancer, not prostate cancer. A neobladder is an artificial bladder made from the patient's intestine, stitched together so the patient continues to pass urine through their natural passage. An ileal conduit instead diverts urine to exit through a different passage into a bag. On quality of life: what matters most in the long run is that the cancer comes out of the body completely; patients adjust well to either option over time.
Answered by Dr.Nitin Shrivastava
Is there a limitation on the number of times TURP can be done on the same patient?
Asked by Moderator
About 10 out of 100 patients will require another TURP within the following 10 years. There is no fixed limit, sometimes the prostate regrows fast and requires re-intervention, and sometimes it's done in stages. The more times TURP is repeated, the higher the chance of complications. Personally, the doctor has done it twice at most on the same patient.
Answered by Dr.Nitin Shrivastava
CT scan is more accessible in our setup than MRI. Is there any place for CT to confirm prostate cancer?
Asked by Moderator
CT scan cannot be used to confirm prostate cancer diagnosis, only MRI can do that. But if MRI isn't available, CT scan is very useful for staging: once a cancer diagnosis is confirmed by biopsy, CT can tell you if it has spread outside the prostate.
Answered by Dr.Nitin Shrivastava
What is the value of PSA to consider dangerous: free PSA, total PSA, PSA ratio?
Asked by Moderator
PSA density above 0.15 is suspicious for cancer. A PSA rise of more than 0.75 per year is also suspicious. These are used alongside the age-adjusted PSA cutoffs (2.5 / 3.5 / 4.5 / 6.5 for the 40s / 50s / 60s / 70s age bands) when a single reading is borderline.
Answered by Dr.Nitin Shrivastava
In case of BPH, what age range is surgery recommended instead of just urine diversion or catheterization?
Asked by Moderator
It is not age but fitness for the procedure that matters. The doctor has operated on a 100-year-old patient, while some patients who are only 60 have too many other diseases and are too high-risk for surgery, and stay on a catheter instead. If a patient has a large prostate requiring long surgery and is high-risk, the choice to proceed with surgery understanding the risk ultimately becomes the patient's own.
Answered by Dr.Nitin Shrivastava
After removal of prostate cancer, there is urine leakage. What is the remedy?
Asked by Moderator
The most practical and best remedy is rehabilitation through Kegel exercises, pelvic floor muscle exercises. If these exercises don't help, an artificial urinary sphincter surgery is available, but that is the last resort.
Answered by Dr.Nitin Shrivastava
What are the nutritional considerations for people with BPH and prostate cancer, and how can urologists and dieticians better collaborate across facilities?
Asked by General Dimma
The main risk factor for prostate cancer remains genetics and family history, but obesity is a genuine risk factor, alcohol's role is controversial, and there is some evidence linking red meat to prostate cancer, along with some supportive evidence for vitamin D, vitamin E, lycopene from tomatoes, and phytoestrogens like soy protein, though none of these are formal recommendations yet. A dietician should always be part of the urology team, since nutrition intersects directly with kidney stones, uric acid and hypertension, alongside a physical therapist to encourage exercise.
Answered by Dr.Nitin Shrivastava
Read the Full Article Series
- 1.Diagnosis and Management of Prostate Cancer: A Complete Guide by Dr. Nitin Shrivastava
- 2.Why Physical Examination Still Matters in Prostate Cancer
- 3.PSA Testing: Age-Adjusted Thresholds, Density and Velocity
- 4.Who Needs Earlier Prostate Cancer Screening
- 5.When to Biopsy: Balancing Missed Cancer Against Overtreatment
- 6.Biopsy Technique and Imaging: Transrectal vs Transperineal, CT vs MRI
- 7.Managing BPH: From Lifestyle to Alpha-Blockers to Surgery
- 8.TURP: How Often It Can Be Repeated, and the Real Tradeoff
- 9.After Prostate Surgery: Incontinence, Neobladder and Quality of Life
- 10.Nutrition and Multidisciplinary Care in Prostate Cancer
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