Chief, Pain Medicine & Palliative Care, Artemis Hospitals, Gurgaon, India
Part 10 of 12 in Advances in Chronic Pain Management
Knee Pain Without Surgery: Cooled Radiofrequency Ablation and Regenerative Options
June 8, 2025
Some patients with severely deformed, advanced arthritic knees genuinely need surgery. But a meaningful group cannot or will not undergo it, whether from dilated cardiomyopathy, advanced age, poor muscle mass or other risk factors. For them, Dr. Jain's practice offers cooled radiofrequency ablation of the genicular nerves as a palliative pain-management procedure, giving on average 12 to 18 months of relief and around 70% pain reduction, combined afterward with braces to correct deformity and support rehabilitation. He describes a patient from Lucknow with an ejection fraction of 15% and an implanted cardiac defibrillator, whom no surgeon would operate on and who had been bed-bound for months; after radiofrequency ablation, she was able to walk again and resume basic daily activities such as cooking and using the toilet.
For osteoarthritis up to grade 3, regenerative options performed under ultrasound guidance include platelet-rich plasma and mesenchymal stem cell injections; for international patients who cannot return monthly for repeat platelet therapy, a one-time mesenchymal stem cell implant is available as an approved alternative with good reported results. For heel pain from plantar fasciitis, the practice has moved from fluoroscopic to ultrasound-guided injection, and generally avoids steroid, since it can rupture the fascia, using platelet injections instead, typically two to three sittings one month apart.
This guide is based on a live Jivo Masterclass — Dr. Ashu Kumar Jain taught doctors across Africa on June 8, 2025.
FROM THE LIVE Q&A
Moderator
The physiology of the drug and the brain's receptors are the same either way, so why is not it habit-forming in sickle cell disease and cancer the way it is elsewhere?
Dr. Ashu Kumar Jain
Because sickle cell pain and cancer pain are primarily visceral pain, and viscera carry opioid receptors. Back pain, knee pain, elbow pain and shoulder pain are peripheral, musculoskeletal or neuropathic pain, and that tissue does not carry the same opioid receptor expression. Visceral pain is also carried by the body's sympathetic nervous system, which does not respond to conventional painkillers, so it needs a neuropathic agent and an opioid in combination. That is the physiological difference.
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Frequently Asked Questions
Would marijuana-based therapy sit in the same class as opioids for safety?▼
Marijuana is a safer drug than a typical opioid, including for musculoskeletal as well as visceral pain, and some countries now use synthetic formulations of it. It just is not approved for medical use in India yet.
NSAIDs also carry a risk of kidney damage for musculoskeletal pain. What is the practical limit?▼
For a musculoskeletal complaint, an NSAID and a muscle relaxant should not run past seven to ten days, at most two weeks. With a new patient, the first move is not intervention: a two-week medical trial is given first, against a target of at least 50% pain relief. If that trial fails to deliver it, the next step is intervention, straight away.
Is there a list of drugs under your remit that are specialist-prescription only, and how do you manage the supply side, including the shelf life and storage of these medicines?▼
In India, opioids are scheduled drugs. Prescribing requires a competent doctor, meaning a pain specialist, anaesthesiologist or neurologist, not a general physician, general surgeon or ENT. For morphine and fentanyl specifically, the hospital needs a government licence to hold a set quantity, uses a special designated government form that gets stamped, and patients are required to bring back a consumption chart that is submitted to the drug controller. Tramadol, tapentadol and buprenorphine do not need that special licensing, but they still require a valid, stamped prescription from a competent doctor.
Given that supply and prescription control is so tight for opioids, is not it strange that some restricted painkiller combinations are still sold over the counter in India?▼
That gap exists, and it falls to drug inspectors to enforce, not to prescribing doctors. In practice it means a large number of chronic pain patients arrive in this clinic having self-medicated with over-the-counter combination painkillers for five, ten, even twenty years. This practice calls it analgesic abuse: a difficult situation created by the fact that these medicines are freely available without a prescription.
What are the most common misconceptions community doctors have about facet joint injection?▼
The first problem is diagnosis. Ninety per cent of doctors who are not trained for this kind of spinal pain cannot diagnose facetogenic pain. This practice groups facetogenic and discogenic pain together as axial pain, and gabapentinoids have no role in treating it, yet eight in ten axial pain patients are put on these drugs anyway, with zero results. Getting it right needs a specific history, a specific examination, and then a diagnostic block to confirm the pain is actually coming from the facet before moving to facet joint radiofrequency ablation.
What is cooled radiofrequency ablation for the knee used for?▼
For patients with advanced knee arthritis who cannot or will not have surgery, whether due to cardiac risk, age or muscle mass. It gives around 70% pain relief lasting 12 to 18 months on average.
What is the one-time alternative for international patients who cannot return monthly for knee treatment?▼
A one-time mesenchymal stem cell implant, offered as an alternative to repeat monthly platelet-rich plasma therapy, for osteoarthritis up to grade 3.
Why is steroid avoided for plantar fasciitis (heel pain)?▼
Because injecting steroid directly into the plantar fascia can cause it to rupture. Platelet injection is used instead, typically over two to three sittings a month apart.
In This Series: Advances in Chronic Pain Management
- 1.Advances in Chronic Pain Management
- 2.Facial Pain: Trigeminal Neuralgia, Glossopharyngeal Neuralgia and Sphenopalatine Ganglion Block
- 3.Cervicogenic Headache and Neck Pain: Cervical Facet Radiofrequency Ablation
- 4.Cervical Radiculopathy: Epidural Injection and Why Cathlab Safety Matters
- 5.Thoracic Facetogenic Pain and T2-T3 Sympathectomy for the Upper Limb
- 6.Shoulder Pain Without Surgery: Adhesive Capsulitis and the Three-in-One Block
- 7.Failed Back Surgery, Sciatica and SI Joint Pain: Transforaminal Adhesiolysis and Facet RFA
- 8.Discogenic Low Back Pain: Biacuplasty and Intradiscal Radiofrequency Ablation
- 9.Cancer, Pelvic and Perineal Pain: Visceral Nerve Blocks and Ganglion Impar
- 10.Knee Pain Without Surgery: Cooled Radiofrequency Ablation and Regenerative Options
- 11.Spinal Cord Stimulation and Intrathecal Pumps for Pain That Doesn't Respond to Anything Else
- 12.Opioids and Sickle Cell Pain: When They Are Habit-Forming and When They Are Not