CardiologyDr. Biswarup PurkayasthaCoronary Artery Disease

Consultant - Heart & Lung Transplant and Vascular Surgery, Artemis Hospitals, Gurgaon

Part 6 of 12 in Diagnosis & Management of Coronary Artery Disease

Confirming the Diagnosis: ECG Patterns, Troponin Testing and the Baseline Blood Panel

November 30, 2025

Reading the ECG

Dr. Biswarup Purkayastha walked through three ECG patterns general practitioners need to distinguish: a normal PQRST tracing, an ST-elevation myocardial infarction (STEMI) with the ST segment raised above baseline, and a non-ST-elevation myocardial infarction (NSTEMI) with the ST segment depressed. Any patient presenting with chest pain and one of the abnormal patterns, with or without enzyme confirmation yet available, should be treated with a high index of suspicion for an infarction while the rest of the workup is completed.

A troponin test that works outside a full lab

For enzyme confirmation, Purkayastha highlighted a point-of-care troponin T kit manufactured by Roche and sold under the Tropy brand in many markets. A blood sample applied to the kit returns two lines for a positive result. He was clear that no single piece of evidence, ECG, symptoms, or enzyme test, is sufficient alone; the diagnosis is made when an ongoing anginal or heartburn-like symptom picture, ECG changes, and a positive enzyme result are present together.

The baseline blood panel

For any patient scoring high on a cardiovascular disease risk assessment, Purkayastha referenced UK NHS guidance for a baseline panel: a full blood count to catch anemia or a clotting abnormality; creatinine, to establish kidney function ahead of choosing medications and contrast agents; liver function tests, historically used as an infarction marker before troponin assays existed; a clotting profile including INR, to guide anticoagulant choice between warfarin, unfractionated heparin and low molecular weight heparin; HbA1c every three months for every diabetic patient; and BNP and CRP as inflammatory markers.

On the inflammatory markers specifically: a BNP above 1000 signals heart failure and a patient more predisposed to coronary disease, while an elevated CRP can indicate a recent infarction within the last one to two days, reflecting inflammation rather than infection. Purkayastha's broader instruction to general practitioners was procedural: maintain a record, whether a formal EMR or otherwise, for every patient's numbers, because that record is what allows risk stratification into high, moderate and low categories, and the higher the risk category, the faster a chest pain presentation should be treated as a probable infarction.

This guide is based on a live Jivo Masterclass — Dr. Biswarup Purkayastha taught doctors across Africa on November 30, 2025.

FROM THE LIVE Q&A

DR

Dr. Dimma (Ghana, relayed by moderator)

Is there a direct relationship between pectoralis muscle spasm and coronary artery disease, and if so, what is the first-choice management?

BP

Dr. Biswarup Purkayastha

The two are differentiated by troponin: a pectoralis muscle spasm will always return a negative troponin test. There is not really a single first-choice management for a direct link between the two, because they do not co-occur as one diagnosis; one patient might have non-cardiac chest pain from a muscle spasm and separately have coronary disease. Treat each on its own terms: non-steroidal anti-inflammatory drugs for the muscle spasm, and the angiography pathway, deciding between angioplasty and bypass, if there is genuine coronary disease.

See all 10 questions from this masterclass →

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Frequently Asked Questions

Can you explain the relationship between optimal nutrition and coronary artery disease risk?

Optimal nutrition means a high-protein, high-fiber, low-fat, low-carbohydrate diet. Combined with the rest of the prevention checklist, no smoking, more than two hours of exercise a week, regular stress management, and routine blood work from age 40 onward, this kind of consistent lifestyle management can prevent coronary artery disease from progressing to the point of needing an intervention in roughly 80 percent of patients.

A 70-year-old diabetic patient with end-stage renal disease, on hemodialysis for three and a half years, on aspirin and atorvastatin, is admitted with intermittent chest pain and a diagnosis of NSTEMI. What should be the next steps?

Start with single antiplatelet therapy, aspirin, and unfractionated heparin rather than low molecular weight heparin, which recirculates in patients with compromised renal clearance. Dose the heparin roughly three times a day for about two weeks to get him through the acute crisis. Once his symptoms settle and he has had his dialysis, plan a coronary angiogram to decide between stenting and bypass. In a frail, elderly diabetic dialysis patient like this, stenting is usually the better option: it buys time with a much shorter recovery than an operation he may not tolerate well.

Can a coronary spasm affect or cause a pectoralis muscle spasm?

No. A pectoralis muscle spasm is aggravated by a localized range-of-motion test, reaching an arm behind the back, for example, while true angina is unaffected by arm or shoulder movement. The two are mechanistically unrelated: manage the muscle spasm with non-steroidal anti-inflammatory drugs and treat a genuine coronary spasm as coronary disease.

What are the alternatives to a frozen elephant trunk (FET) procedure for aortic dissection?

If a frozen elephant trunk has not been done, the alternative is EVAR, endovascular aortic repair, sealing off the re-entry tear with a stent graft placed through the groin. In the thoracic aorta this is straightforward because there are no major branch vessels to route around. In the abdominal aorta, where the gastroepiploic, superior mesenteric, renal and inferior mesenteric arteries branch off, patient-specific imaging has to be sent to a stent graft manufacturer so they can build a graft with branches positioned at the right levels before it is deployed.

How should a general practitioner judge whether a coronary artery disease case needs a specialist referral, domestically or abroad, versus continued management at the primary care level?

Complexity is determined by the workup, not by symptoms alone. Watch the troponin and creatine kinase trend: if enzymes keep rising, or symptoms have not improved after 72 to 96 hours of conservative therapy, antiplatelet medication, or thrombolysis where that pathway was used, that is the signal to make a specialist referral so a senior physician can perform an angiogram and determine disease severity directly.

What are the three ECG patterns used to assess coronary artery disease?

A normal PQRST tracing, an ST-elevation myocardial infarction (STEMI) with the ST segment raised above baseline, and a non-ST-elevation myocardial infarction (NSTEMI) with the ST segment depressed.

How does a point-of-care troponin test work?

A blood sample is applied to a kit, such as the Roche Tropy-branded troponin T test, and two lines on the strip indicate a positive result for myocardial infarction.

What combination of findings is needed to confirm a myocardial infarction diagnosis?

The symptom picture, ECG changes and a positive enzyme result together. None of the three is sufficient evidence on its own.

What does a BNP level above 1000 indicate?

It signals heart failure and marks a patient as more predisposed to coronary disease, distinct from an elevated CRP, which more often reflects a recent infarction's inflammation rather than infection.

What baseline blood tests should a high cardiovascular-risk patient receive?

A full blood count, creatinine, liver function tests, a clotting profile including INR, HbA1c every three months for diabetics, and BNP and CRP as inflammatory markers.

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