CardiologyDr. Biswarup PurkayasthaCoronary Artery Disease

Consultant - Heart & Lung Transplant and Vascular Surgery, Artemis Hospitals, Gurgaon

Part 9 of 12 in Diagnosis & Management of Coronary Artery Disease

Total Arterial Revascularization: Replacing an Artery with an Artery

November 30, 2025

Within coronary bypass surgery itself, Dr. Biswarup Purkayastha draws a further distinction between grafts built from leg veins and grafts built entirely from arteries harvested from the chest wall, a technique known as total arterial revascularization. His stated principle is direct: a coronary artery is best replaced with an artery, not a vein, and he performs total arterial revascularization in roughly 60 to 70 percent of his own coronary bypass cases.

The outcomes data

To support the approach, Purkayastha cited data he attributed to the Annals of Thoracic Surgery covering close to 4,000 patients treated between 2011 and 2018, of whom around 2,700 underwent percutaneous intervention (stenting) and roughly 1,300 underwent CABG. In that dataset, mortality with CABG was roughly 13 percent against roughly 26 percent for stenting, and CABG was associated with roughly half the rate of major adverse cardiovascular and cerebrovascular events (around 28 percent versus around 60 percent for stenting).

The procedure and recovery

Describing the operation itself, Purkayastha explained that the chest is opened via the breastbone, a stabilizing device called an octopus is placed to immobilize the section of heart being grafted, and the arterial grafts are then connected to bypass the blocked coronary segments. He offered a recent example from his own practice: a patient revascularized the night before was awake, off inotropic support, and mobilizing himself the next day, with cardiac function improved from an ejection fraction of roughly 40 percent to 50 percent, and without significant chest pain or wound-healing problems.

His closing recommendation to general practitioners making a referral: specify in the referral note, wherever it is even remotely feasible, that the patient should be considered for a total arterial revascularization, since in his assessment this choice affects a patient's outcome over decades rather than years.

This guide is based on a live Jivo Masterclass — Dr. Biswarup Purkayastha taught doctors across Africa on November 30, 2025.

FROM THE LIVE Q&A

DR

Dr. Dimma (Ghana, relayed by moderator)

Can a coronary spasm affect or cause a pectoralis muscle spasm?

BP

Dr. Biswarup Purkayastha

No. A pectoralis muscle spasm is aggravated by a localized range-of-motion test, reaching an arm behind the back, for example, while true angina is unaffected by arm or shoulder movement. The two are mechanistically unrelated: manage the muscle spasm with non-steroidal anti-inflammatory drugs and treat a genuine coronary spasm as coronary disease.

See all 10 questions from this masterclass →

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Frequently Asked Questions

What are the alternatives to a frozen elephant trunk (FET) procedure for aortic dissection?

If a frozen elephant trunk has not been done, the alternative is EVAR, endovascular aortic repair, sealing off the re-entry tear with a stent graft placed through the groin. In the thoracic aorta this is straightforward because there are no major branch vessels to route around. In the abdominal aorta, where the gastroepiploic, superior mesenteric, renal and inferior mesenteric arteries branch off, patient-specific imaging has to be sent to a stent graft manufacturer so they can build a graft with branches positioned at the right levels before it is deployed.

How should a general practitioner judge whether a coronary artery disease case needs a specialist referral, domestically or abroad, versus continued management at the primary care level?

Complexity is determined by the workup, not by symptoms alone. Watch the troponin and creatine kinase trend: if enzymes keep rising, or symptoms have not improved after 72 to 96 hours of conservative therapy, antiplatelet medication, or thrombolysis where that pathway was used, that is the signal to make a specialist referral so a senior physician can perform an angiogram and determine disease severity directly.

A 38-year-old man has had two years of intermittent chest pain, breathlessness and weakness, with two ECGs, two echocardiograms, a full blood panel and a 24-hour Holter all largely unremarkable, and no local access to CT coronary angiography. What is the next step?

One ECG showing borderline bradycardia, combined with a two-year history that has defeated standard testing, points toward right coronary artery disease, which is notoriously difficult to pick up outside direct angiography. Pending access to a coronary angiogram, start dual antiplatelet therapy, 75 mg of clopidogrel and 150 mg of aspirin daily, plus a statin at 40 mg daily to stabilize the plaque, and check cardiac enzymes at his next chest pain episode. A positive enzyme without an ECG change would classify him as unstable angina, since that diagnosis only requires a troponin derangement alongside chest pain, not an ECG change. A strong maternal family history of cardiac illness is relevant here even though he is young and does not smoke or drink.

What about the RFCL, risk factor weighted clinical likelihood, score? It placed this same patient at 10 percent.

RFCL is an old scoring system we do not use anymore; it produces more false negatives than anything useful. Score this patient with a EuroSCORE now, and a SYNTAX score once an angiogram is available.

Can you say more about coronary artery disease in menopausal women, and about the sympathetic nerve involvement you mentioned in diabetics?

Before 45, women have high estrogen and regular cycles, giving them roughly one-eighth the coronary risk of a man. After menopause, that risk is still about half of a man's, but it rises four-fold from her own prior baseline. The presentation also changes: expect a longer course, days rather than hours, with softer symptoms, a flu-like feeling or mild chest tightness, that get mistaken for a common cold. The best test in this group is a CT coronary angiogram, because women tend to have a lower coronary calcium load, which gives CT angiography a strong positive predictive value for them specifically. Diabetics have a parallel but distinct problem: autonomic nerve involvement blunts the pain signal, so they report less chest pain for the same severity of disease while still showing the nausea, fatigue and cold extremities of an infarction. Physicians need to actively look for the disease in diabetics rather than wait for classic pain.

What is total arterial revascularization in coronary bypass surgery?

A bypass technique that uses grafts built entirely from arteries harvested from the chest wall, rather than veins taken from the leg, on the principle that a coronary artery is best replaced with an artery.

How do bypass surgery and stenting compare on mortality and complication rates?

In a cited dataset of close to 4,000 patients treated between 2011 and 2018, CABG showed roughly 13 percent mortality against roughly 26 percent for stenting, and roughly half the rate of major adverse cardiovascular and cerebrovascular events.

What device is used to stabilize the heart during off-pump bypass grafting?

A stabilizing device known as an octopus, which immobilizes the section of heart being grafted while the arterial connections are made.

What should a referral note specify when recommending a patient for bypass surgery?

That the patient be considered for total arterial revascularization wherever it is even remotely feasible, since the choice affects patient outcomes over decades rather than years.

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