CardiologyDr. Biswarup PurkayasthaCoronary Artery Disease

Consultant - Heart & Lung Transplant and Vascular Surgery, Artemis Hospitals, Gurgaon

Part 4 of 12 in Diagnosis & Management of Coronary Artery Disease

Why Diabetics and Postmenopausal Women Present Atypically with Heart Attacks

November 30, 2025

Diabetics: less pain, not less disease

Dr. Biswarup Purkayastha flagged diabetic patients as a group that general practitioners systematically under-triage, because diabetic autonomic neuropathy, damage to the nerves that carry pain and other sympathetic signals, blunts the pain signal itself. A diabetic having a heart attack will often report less chest pain than a non-diabetic having the same event, while still carrying the nausea, extreme tiredness and cold, clammy extremities that accompany an infarction. Purkayastha's guidance is that physicians treating diabetic patients need to be primed to recognize this subtler presentation and not wait for a textbook level of chest pain before investigating.

Estrogen, menopause, and a four-fold shift in risk

Purkayastha quantified the sex-based risk shift directly: a woman under roughly 45, still cycling and with normal estrogen levels, carries about one-eighth the coronary risk of a man of the same age, a protective effect he attributed to estrogen. After menopause, that risk still sits at roughly half of a man's risk in absolute terms, but it rises four-fold relative to the woman's own pre-menopausal baseline.

The clinical consequence is a longer, softer symptom course. Postmenopausal women, Purkayastha said, may present with what looks like a mild flu, a little chest tightness, or general uneasiness lasting several days, symptoms easily dismissed with over-the-counter treatment. His specific recommendation for this group is a CT coronary angiogram, which he noted performs especially well in women because they typically have a lower coronary calcium load, giving CT angiography a strong positive predictive value in this population. Any woman over 45 reporting several days of mild but persistent chest discomfort, in his framing, warrants that workup rather than a reflexive diagnosis of a cold or indigestion.

This guide is based on a live Jivo Masterclass — Dr. Biswarup Purkayastha taught doctors across Africa on November 30, 2025.

FROM THE LIVE Q&A

DR

Dr. Boris Pachinko (general practitioner, Zambia)

Can you say more about coronary artery disease in menopausal women, and about the sympathetic nerve involvement you mentioned in diabetics?

BP

Dr. Biswarup Purkayastha

Before 45, women have high estrogen and regular cycles, giving them roughly one-eighth the coronary risk of a man. After menopause, that risk is still about half of a man's, but it rises four-fold from her own prior baseline. The presentation also changes: expect a longer course, days rather than hours, with softer symptoms, a flu-like feeling or mild chest tightness, that get mistaken for a common cold. The best test in this group is a CT coronary angiogram, because women tend to have a lower coronary calcium load, which gives CT angiography a strong positive predictive value for them specifically. Diabetics have a parallel but distinct problem: autonomic nerve involvement blunts the pain signal, so they report less chest pain for the same severity of disease while still showing the nausea, fatigue and cold extremities of an infarction. Physicians need to actively look for the disease in diabetics rather than wait for classic pain.

See all 10 questions from this masterclass →

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Frequently Asked Questions

How do you manage an angina case in a patient who is HIV positive?

The same as anyone else. He gets a coronary angiogram under a universal precautions pathway, and if he has coronary artery disease, it is stentable or operable exactly as it would be otherwise. Any JCI-accredited hospital, ours included, has a protocol to isolate and properly treat these patients. People living with HIV are not discriminated against in access to stenting or bypass surgery.

Is there a direct relationship between pectoralis muscle spasm and coronary artery disease, and if so, what is the first-choice management?

The two are differentiated by troponin: a pectoralis muscle spasm will always return a negative troponin test. There is not really a single first-choice management for a direct link between the two, because they do not co-occur as one diagnosis; one patient might have non-cardiac chest pain from a muscle spasm and separately have coronary disease. Treat each on its own terms: non-steroidal anti-inflammatory drugs for the muscle spasm, and the angiography pathway, deciding between angioplasty and bypass, if there is genuine coronary disease.

Can you explain the relationship between optimal nutrition and coronary artery disease risk?

Optimal nutrition means a high-protein, high-fiber, low-fat, low-carbohydrate diet. Combined with the rest of the prevention checklist, no smoking, more than two hours of exercise a week, regular stress management, and routine blood work from age 40 onward, this kind of consistent lifestyle management can prevent coronary artery disease from progressing to the point of needing an intervention in roughly 80 percent of patients.

A 70-year-old diabetic patient with end-stage renal disease, on hemodialysis for three and a half years, on aspirin and atorvastatin, is admitted with intermittent chest pain and a diagnosis of NSTEMI. What should be the next steps?

Start with single antiplatelet therapy, aspirin, and unfractionated heparin rather than low molecular weight heparin, which recirculates in patients with compromised renal clearance. Dose the heparin roughly three times a day for about two weeks to get him through the acute crisis. Once his symptoms settle and he has had his dialysis, plan a coronary angiogram to decide between stenting and bypass. In a frail, elderly diabetic dialysis patient like this, stenting is usually the better option: it buys time with a much shorter recovery than an operation he may not tolerate well.

Can a coronary spasm affect or cause a pectoralis muscle spasm?

No. A pectoralis muscle spasm is aggravated by a localized range-of-motion test, reaching an arm behind the back, for example, while true angina is unaffected by arm or shoulder movement. The two are mechanistically unrelated: manage the muscle spasm with non-steroidal anti-inflammatory drugs and treat a genuine coronary spasm as coronary disease.

Why do diabetic patients often report less chest pain during a heart attack?

Diabetic autonomic neuropathy blunts the pain signal itself. The patient will still show nausea, extreme tiredness and cold, clammy extremities, just with less of the classic chest pain.

How much does menopause change a woman's coronary risk?

Before roughly 45, a woman carries about one-eighth the coronary risk of a man of the same age. After menopause, that risk still sits at roughly half of a man's risk in absolute terms, but rises four-fold relative to her own pre-menopausal baseline.

What is the best imaging test for suspected coronary disease in postmenopausal women?

A CT coronary angiogram, which performs especially well in this group because women typically have a lower coronary calcium load, giving the test a strong positive predictive value.

What symptoms in a postmenopausal woman should prompt a cardiac work-up rather than a cold or indigestion diagnosis?

Several days of a mild flu-like illness, chest tightness, or general uneasiness. That presentation, rather than classic severe chest pain, is the pattern to probe further in this age group.

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