CardiologyDr. Biswarup PurkayasthaCoronary Artery Disease

Consultant - Heart & Lung Transplant and Vascular Surgery, Artemis Hospitals, Gurgaon

Part 2 of 12 in Diagnosis & Management of Coronary Artery Disease

Recognizing Coronary Artery Disease Before It Becomes a Heart Attack

November 30, 2025

Coronary artery disease develops before it announces itself as a heart attack, and the interval between the two is where early intervention has the most leverage. Dr. Biswarup Purkayastha frames the early symptom set broadly: chest pain, dyspnea (shortness of breath), unusual fatigue, pain in the legs, a generalized feeling of being unwell, and weakness. Any one of these, appearing where it did not before, is sufficient reason to see a general practitioner.

The practical marker Purkayastha suggests is functional decline relative to a recent baseline: a patient who can no longer independently do tasks they managed comfortably a month or two earlier is describing a meaningful change, even if no single symptom sounds dramatic on its own. He was explicit that these warning signs tend to appear in the disease course well before a myocardial infarction, which is exactly why they are easy to under-report and easy for a first-contact physician to miss.

Heartburn is not always heartburn

One of the more actionable distinctions Purkayastha raised concerns cardiac symptoms that mimic digestive complaints. A heartburn-like sensation is common in men presenting with early coronary disease, and it is routinely treated with over-the-counter antacids. His guidance: if that heartburn persists for more than half an hour after taking the standard antacid or indigestion medication, that is the signal to see a general practitioner immediately rather than reach for a second dose.

Why early referral changes the trajectory

Purkayastha's broader point is that these symptoms are a physician's best opportunity to intervene before the disease reaches the point of an infarction. Once a patient reaches the emergency stage, the treatment options narrow considerably; the earlier stage is where lifestyle changes, medical therapy and risk stratification can still change the outcome without an intervention.

This guide is based on a live Jivo Masterclass — Dr. Biswarup Purkayastha taught doctors across Africa on November 30, 2025.

FROM THE LIVE Q&A

DR

Dr. Boris Pachinko (general practitioner, Zambia)

A 38-year-old man has had two years of intermittent chest pain, breathlessness and weakness, with two ECGs, two echocardiograms, a full blood panel and a 24-hour Holter all largely unremarkable, and no local access to CT coronary angiography. What is the next step?

BP

Dr. Biswarup Purkayastha

One ECG showing borderline bradycardia, combined with a two-year history that has defeated standard testing, points toward right coronary artery disease, which is notoriously difficult to pick up outside direct angiography. Pending access to a coronary angiogram, start dual antiplatelet therapy, 75 mg of clopidogrel and 150 mg of aspirin daily, plus a statin at 40 mg daily to stabilize the plaque, and check cardiac enzymes at his next chest pain episode. A positive enzyme without an ECG change would classify him as unstable angina, since that diagnosis only requires a troponin derangement alongside chest pain, not an ECG change. A strong maternal family history of cardiac illness is relevant here even though he is young and does not smoke or drink.

See all 10 questions from this masterclass →

Book a Consultation with Dr. Biswarup Purkayastha

Book on WhatsApp

Or message us on WhatsApp: +91 98182 98669

Frequently Asked Questions

What about the RFCL, risk factor weighted clinical likelihood, score? It placed this same patient at 10 percent.

RFCL is an old scoring system we do not use anymore; it produces more false negatives than anything useful. Score this patient with a EuroSCORE now, and a SYNTAX score once an angiogram is available.

Can you say more about coronary artery disease in menopausal women, and about the sympathetic nerve involvement you mentioned in diabetics?

Before 45, women have high estrogen and regular cycles, giving them roughly one-eighth the coronary risk of a man. After menopause, that risk is still about half of a man's, but it rises four-fold from her own prior baseline. The presentation also changes: expect a longer course, days rather than hours, with softer symptoms, a flu-like feeling or mild chest tightness, that get mistaken for a common cold. The best test in this group is a CT coronary angiogram, because women tend to have a lower coronary calcium load, which gives CT angiography a strong positive predictive value for them specifically. Diabetics have a parallel but distinct problem: autonomic nerve involvement blunts the pain signal, so they report less chest pain for the same severity of disease while still showing the nausea, fatigue and cold extremities of an infarction. Physicians need to actively look for the disease in diabetics rather than wait for classic pain.

How do you manage an angina case in a patient who is HIV positive?

The same as anyone else. He gets a coronary angiogram under a universal precautions pathway, and if he has coronary artery disease, it is stentable or operable exactly as it would be otherwise. Any JCI-accredited hospital, ours included, has a protocol to isolate and properly treat these patients. People living with HIV are not discriminated against in access to stenting or bypass surgery.

Is there a direct relationship between pectoralis muscle spasm and coronary artery disease, and if so, what is the first-choice management?

The two are differentiated by troponin: a pectoralis muscle spasm will always return a negative troponin test. There is not really a single first-choice management for a direct link between the two, because they do not co-occur as one diagnosis; one patient might have non-cardiac chest pain from a muscle spasm and separately have coronary disease. Treat each on its own terms: non-steroidal anti-inflammatory drugs for the muscle spasm, and the angiography pathway, deciding between angioplasty and bypass, if there is genuine coronary disease.

Can you explain the relationship between optimal nutrition and coronary artery disease risk?

Optimal nutrition means a high-protein, high-fiber, low-fat, low-carbohydrate diet. Combined with the rest of the prevention checklist, no smoking, more than two hours of exercise a week, regular stress management, and routine blood work from age 40 onward, this kind of consistent lifestyle management can prevent coronary artery disease from progressing to the point of needing an intervention in roughly 80 percent of patients.

What are the early warning signs of coronary artery disease before a heart attack occurs?

Chest pain, breathlessness, unusual fatigue, pain in the legs, a generalized feeling of being unwell, and weakness. Any one of these on its own is reason enough to see a general practitioner.

How can someone tell whether fatigue is a meaningful warning sign rather than normal tiredness?

The practical marker is functional decline relative to a recent baseline: no longer being able to do independently, comfortably, the tasks that were manageable a month or two earlier.

When does heartburn stop being ordinary heartburn?

If it persists for more than half an hour after a standard over-the-counter antacid or indigestion medication, that is the signal to see a general practitioner immediately rather than take a second dose.

Why does catching these early symptoms matter so much for treatment outcomes?

They tend to appear in the disease course well before a myocardial infarction. That earlier stage is where lifestyle changes, medical therapy and risk stratification can still change the outcome without a surgical or percutaneous intervention.

Need Expert Medical Guidance?

Connect with leading specialists through the Jivo Healthcare network for personalized advice.

Get Expert Opinion